Integrative Analysis of Pulmonary Sarcomatoid Carcinoma (PSC)

NCT ID: NCT04215913

Last Updated: 2020-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-30

Study Completion Date

2025-12-24

Brief Summary

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Integrative Analysis of pulmonary sarcomatoid carcinoma (PSC)

Detailed Description

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The investigators will analyzed proteomes of paired normal lung tissues and pulmonary sarcomatoid carcinoma with or without metastasis, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal lung tissue, primary pulmonary sarcomatoid carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of lung cancer characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.

Conditions

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Lung Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Normal lung tissue

Normal lung tissue from PSC patients

The investigators will extract total protein, DNA and RNA from PSC patients.

Intervention Type OTHER

The investigators will extract total protein, DNA and RNA from PSC patients.

PSC tissues

PSC tissues from PSC patients

The investigators will extract total protein, DNA and RNA from PSC patients.

Intervention Type OTHER

The investigators will extract total protein, DNA and RNA from PSC patients.

Metastasis tissues

Metastasis tissues from PSC patients

The investigators will extract total protein, DNA and RNA from PSC patients.

Intervention Type OTHER

The investigators will extract total protein, DNA and RNA from PSC patients.

Interventions

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The investigators will extract total protein, DNA and RNA from PSC patients.

The investigators will extract total protein, DNA and RNA from PSC patients.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≤ 70 years with histologically proven LCLC
* No severe major organ dysfunction
* World Health Organization (WHO) performance status of 0 or 1
* No prior cancer chemotherapy

Exclusion Criteria

* Age ≥ 70
* Severe major organ dysfunction
* WHO performance status of \>1
* Prior cancer chemotherapy
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China

OTHER

Sponsor Role collaborator

Anhui Medical University

OTHER

Sponsor Role collaborator

Shanghai 10th People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Da Fu

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Da Fu

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

References

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Boland JM, Mansfield AS, Roden AC. Pulmonary sarcomatoid carcinoma-a new hope. Ann Oncol. 2017 Jul 1;28(7):1417-1418. doi: 10.1093/annonc/mdx276. No abstract available.

Reference Type RESULT
PMID: 28637281 (View on PubMed)

Other Identifiers

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FD52Rainy

Identifier Type: REGISTRY

Identifier Source: secondary_id

2019-FD52Rainy-PSC

Identifier Type: -

Identifier Source: org_study_id

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