Integrative Analysis of Large-cell Lung Cancer

NCT ID: NCT02917369

Last Updated: 2016-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2026-12-31

Brief Summary

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Integrative analysis of LCLC

Detailed Description

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The investigators will analyzed proteomes of paired normal lung tissues and LCLC with or without liver metastasis, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal lung tissue, primary LCLC carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of lung cancer characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.

Conditions

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Lung Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Normal lung tissue

Normal lung tissue from LCLC patients

Normal lung tissue

Intervention Type OTHER

The investigators will extract total protein, DNA and RNA from LCLC patients.

LCLC tissues

LCLC tissues from LCLC patients

Normal lung tissue

Intervention Type OTHER

The investigators will extract total protein, DNA and RNA from LCLC patients.

Metastasis tissues

Metastasis tissues from LCLC patients

Normal lung tissue

Intervention Type OTHER

The investigators will extract total protein, DNA and RNA from LCLC patients.

Interventions

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Normal lung tissue

The investigators will extract total protein, DNA and RNA from LCLC patients.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≤ 75 years with histologically proven LCLC
* No severe major organ dysfunction
* World Health Organization (WHO) performance status of 0 or 1
* No prior cancer chemotherapy

Exclusion Criteria

* Age ≥ 76
* Severe major organ dysfunction
* WHO performance status of \>1
* Prior cancer chemotherapy
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Pulmonary Hospital, Shanghai, China

OTHER

Sponsor Role collaborator

Shanghai 10th People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Da Fu

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Da Fu, PhD

Role: PRINCIPAL_INVESTIGATOR

Shanghai 10th People's Hospital

Locations

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Ganzhou City People's Hospital

Ganzhou, Jiangxi, China

Site Status RECRUITING

Shanghai Tenth People's Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Da Fu, PhD

Role: CONTACT

00-86-21-66301604

Facility Contacts

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Xiaoming Zhong, MD

Role: primary

00-86-797-8356156

Da Fu, PhD

Role: primary

00-86-21-66301604

Likun Hou, MD

Role: primary

00-86-21-65115006 ext. 3030

References

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Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4.

Reference Type RESULT
PMID: 25651787 (View on PubMed)

Other Identifiers

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2016-52-Rainy

Identifier Type: -

Identifier Source: org_study_id

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