The Chinese Pulmonary Lymphoepithelioma-like Carcinoma Collaboration Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

10000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-01-01

Study Completion Date

2030-12-31

Brief Summary

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This retrospective case-control study aims to investigate the genetic mechanisms of primary Pulmonary Lymphoepithelioma-like Carcinoma, identify genetic susceptibility loci associated with its onset, and explore potential pathogenic genes, providing new insights for its etiological research.

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Detailed Description

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Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare non-small cell lung cancer (NSCLC) that histologically resembles nasopharyngeal carcinoma (NPC) and predominantly affects the Asian population. Epstein-Barr virus (EBV) infection is a recognized pathogenic factor, and the regional prevalence of pLELC suggests that genetic susceptibility also plays an important role. However, no genetic studies on pLELC have been conducted, leaving its genetic etiology poorly understood. In this study, genotyping for all the subjects was performed by using Illumina Infinium Global Screening Array. Genome-wide association followed by meta-analysis was performed for pLELC cases and healthy controls. The primary objective of this study is to discover susceptibility genes that explain the genetic mechanisms of pLELC.

Conditions

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Primary Pulmonary Lymphoepithelioma-like Carcinoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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SYSUCC cohort, Guangdong, China

Cases:

Patients aged 18 and above with a pathological diagnosis of primary pulmonary lymphoepithelioma-like carcinoma who were treated at the Sun Yat-sen University Cancer Center from January 1, 2002.

Controls:

Healthy participants aged 18 and above.

Genome-wide genotyping

Intervention Type GENETIC

Whole blood from the participants was used to extract DNA for genotyping.

Foshan cohort, Guangdong, China

Cases:

Patients aged 18 and above with a pathological diagnosis of primary pulmonary lymphoepithelioma-like carcinoma who were treated at the the First People's Hospital of Foshan from January 1, 2007.

Controls:

Healthy participants aged 18 and above.

Genome-wide genotyping

Intervention Type GENETIC

Whole blood from the participants was used to extract DNA for genotyping.

Interventions

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Genome-wide genotyping

Whole blood from the participants was used to extract DNA for genotyping.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

The subject is pathologically diagnosed with primary pulmonary lymphoepithelioma-like carcinoma.

The subject is in good physical condition and has a stable level of consciousness;

Exclusion Criteria

The subject is diagnosed with metastatic nasopharyngeal carcinoma; The subject has heavy cardiovascular, liver, or kidney disease.

Controls:

The subject has prevalent cancer; The subject has heavy cardiovascular, liver, or kidney disease.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes