The Effect of Vasopressors on Cerebral Oxygentaion During Off Pump CABG
NCT ID: NCT04214145
Last Updated: 2022-05-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
90 participants
INTERVENTIONAL
2020-01-07
2021-09-03
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Phenylephrine
Phenylephrine
Continuous infusion of Phenylenphrine 250 μg/mL (=Phenylephrine 10mg \* 5@ + D5W 200 mL) if mean BP \< 60mmHg.
1. Initial rate: 0.42 μg/kg/min (=0.1 mL/kg/hr)
2. Increment by 0.21 μg/kg/min (=0.05 mL/kg/hr) if mean BP \< 60mmHg after 5 minutes
3. Maximum rate: 3.33 μg/kg/min (=0.8 mL/kg/hr)
Norepinephrine
Norepinephrine
Continuous infusion of Norepienphrine 20 μg/mL (=NE 4mg \* 1@ + D5W 200 mL) if mean BP \< 60mmHg.
1. Initial rate: 0.03 μg/kg/min (=0.1 mL/kg/hr)
2. Increment by 0.015 μg/kg/min (=0.05 mL/kg/hr) if mean BP \< 60mmHg after 5 minutes
3. Maximum rate: 0.24 μg/kg/min (=0.8 mL/kg/hr)
Vasopressin
Vasopressin
Continuous infusion of Vasopressin 0.1 u/mL (=Vasopressin 20u \* 1@ + D5W 200 mL) if mean BP \< 60mmHg.
1. Initial rate: 0.01 u/kg/hr (=0.1 mL/kg/hr)
2. Increment by 0.005 u/kg/hr (=0.05 mL/kg/hr) if mean BP \< 60mmHg after 5 minutes
3. Maximum rate: 0.08 u/kg/hr (=0.8 mL/kg/hr)
Interventions
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Phenylephrine
Continuous infusion of Phenylenphrine 250 μg/mL (=Phenylephrine 10mg \* 5@ + D5W 200 mL) if mean BP \< 60mmHg.
1. Initial rate: 0.42 μg/kg/min (=0.1 mL/kg/hr)
2. Increment by 0.21 μg/kg/min (=0.05 mL/kg/hr) if mean BP \< 60mmHg after 5 minutes
3. Maximum rate: 3.33 μg/kg/min (=0.8 mL/kg/hr)
Norepinephrine
Continuous infusion of Norepienphrine 20 μg/mL (=NE 4mg \* 1@ + D5W 200 mL) if mean BP \< 60mmHg.
1. Initial rate: 0.03 μg/kg/min (=0.1 mL/kg/hr)
2. Increment by 0.015 μg/kg/min (=0.05 mL/kg/hr) if mean BP \< 60mmHg after 5 minutes
3. Maximum rate: 0.24 μg/kg/min (=0.8 mL/kg/hr)
Vasopressin
Continuous infusion of Vasopressin 0.1 u/mL (=Vasopressin 20u \* 1@ + D5W 200 mL) if mean BP \< 60mmHg.
1. Initial rate: 0.01 u/kg/hr (=0.1 mL/kg/hr)
2. Increment by 0.005 u/kg/hr (=0.05 mL/kg/hr) if mean BP \< 60mmHg after 5 minutes
3. Maximum rate: 0.08 u/kg/hr (=0.8 mL/kg/hr)
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Preoperative vasopressor use
* Preoperative mechanical circulatory support
* Concurrent cerebrovascular or head and neck surgery
* Technical difficulty of measuring brain oxygen saturation
* Redo coronary artery bypass surgery
19 Years
ALL
No
Sponsors
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Seoul National University Hospital
OTHER
Responsible Party
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Yunseok Jeon
Professor
Locations
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Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
Seoul, , South Korea
Countries
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Other Identifiers
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OPCAB_vasopressor
Identifier Type: -
Identifier Source: org_study_id
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