Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery
NCT ID: NCT04679337
Last Updated: 2023-02-14
Study Results
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Basic Information
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COMPLETED
46 participants
OBSERVATIONAL
2020-12-10
2022-12-03
Brief Summary
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Detailed Description
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Near-infrared spectroscopy (NIRS) measures the distribution of oxygenated hemoglobin and deoxygenated hemoglobin in tissues by sending two different near-infrared wavelengths (730 and 810 nm) from the sensor. It is a device that can continuously monitor the oxygen supply-demand balance to a specific region non-invasively. NIRS is mainly used to measure the oxygen demand-supply balance of the cerebral tissue by attaching a sensor to the forehead in the surgical patient. Since it is known to be closely related to the reduction of cerebral oxygen saturation during surgery and the occurrence of postoperative cognitive dysfunction, it is used as an indispensable monitoring device to prevent neurological complications in heart surgery patients. Recently, with technological advances, it has become possible to measure oxygen saturation by attaching sensors to various body tissues other than the brain. When monitored with an NIRS sensor attached to the kidney, the relationship between renal oxygen saturation reduction and postoperative acute kidney injury (AKI) in children and adult patients undergoing heart surgery was reported. However, so far, the effects of systemic hemodynamic and oxygen saturation changes during the displacement of heart for coronary anastomosis during OPCAB on the oxygen saturation in the cerebral cortex and kidney, have not been studied. In addition, it is not known whether the cerebral cortical oxygen saturation (rcSO2), which is commonly used in heart surgery, can reflect the renal oxygen saturation (rrSO2).
The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while displacing the heart for each coronary anastomosis in 19-80 year old adult patients receiving off-pump coronary artery bypass graft surgery (OPCAB) under general anesthesia.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* undergoing off-pump coronary artery bypass graft surgery
Exclusion Criteria
* Hyperbilirubinemia (total bilirubin\> 1.2 mg/dl)
* Kidney disease (serum creatinine 1.5 mg/dl) or chronic kidney failure
* Carotid artery stenosis (\> 60%)
19 Years
80 Years
ALL
No
Sponsors
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Yeungnam University College of Medicine
OTHER
Responsible Party
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Sung Mee Jung
Professor
Locations
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Yeungnam University Medical Center
Daegu, , South Korea
Countries
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Other Identifiers
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YUMC-2020-11-035
Identifier Type: -
Identifier Source: org_study_id
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