End Tidal Anesthetic Concentration in Different Anesthesia Techniques Where Depth of Anesthesia Adjusted With Entropy
NCT ID: NCT04203290
Last Updated: 2022-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
44 participants
INTERVENTIONAL
2019-12-19
2020-07-20
Brief Summary
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Detailed Description
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In cases where TEA is combined with general anesthesia or not, anesthesia depth will be effectively monitored by entropy monitoring, in this way the adequate depth of anesthesia will be provided with the use of minimal volatile anesthetics and we will be able to prevent the use of large amounts of volatile anesthetics., It will be determined how much reduction in alveolar concentration is required in cases combined with TEA.
Nowadays, with the development of reliable anesthesia machines, "low-flow anesthesia" (LFA) is becoming more widespread, and its benefits on patient health, economy and ecology have been demonstrated. In LFA, the depth of anesthesia should not be too superficial or too deep during the time the alveolar concentration of volatile agent reaches equilibrium. Therefore, alveolar concentrations of volatile anesthetics are monitored in modern anesthesia machines. Some machines may also adjust the depth of anesthesia according to the alveolar concentration of the agent.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SCREENING
DOUBLE
Study Groups
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General anesthesia
Patients will be applyed 0.03 mg/kg midazolam, 2 mcg/kg fentanyl, propofol until reaching the appropriate anesthetic depth by observing entropy value (40-60) and 0.5 mg/kg rocuronium for anesthesia induction, after intubation sevoflurane will be used for anesthesia maintenance with low flow anesthesia (0.5 l/min).
Sevoflurane
End tidal sevoflurane concentration
General anesthesia combined with thoracic epidural anesthesia
Before anesthesia induction epidural catheter will be inserted giving 7 ml bupivacaine %0.25 in saline + 50 mcg fentanyl after confirming the location of catheter, following 15 minutes the standard anesthesia induction will be applied ( 0.03 mg/kg midazolam, 2 mcg/kg fentanyl, propofol until reaching the appropriate anesthetic depth by observing entropy value (40-60) and 0.5 mg/kg rocuronium ). For anesthesia maintenance epidural infusion will be applied ( 7ml/h %0.25 bupivacaine solution) together with low flow (0.5 l/min) sevoflurane anesthesia.
Bupivacaine
%0.25 bupivacaine solution
Sevoflurane
End tidal sevoflurane concentration
Interventions
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Bupivacaine
%0.25 bupivacaine solution
Sevoflurane
End tidal sevoflurane concentration
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients who will not undergoing operation for thoracic cavity
* Body Mass Index (BMI) between 20-30
Exclusion Criteria
* contraindications for thoracic epidural anesthesia
* patients who are FEV1/FVC \< 60
* patients with thoracic and lomber vertebrae surgery
18 Years
65 Years
ALL
No
Sponsors
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Istanbul University
OTHER
Responsible Party
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Nuzhet Mert Senturk, MD, Prof
Professor
Principal Investigators
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Nuzhet Mert Shenturk, MD, Prof
Role: PRINCIPAL_INVESTIGATOR
Istanbul University Faculty of Medicine Department of Anesthesiology
Locations
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İstanbul University
Istanbul, , Turkey (Türkiye)
Countries
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Related Links
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Epidural lidocaine decreases sevoflurane requirement for adequate depth of anesthesia as measured by the BIS monitor
Comparison of the effects of thoracic and lumbar epidural anesthesia on induction and maintenance doses of propofol during total i.v. anesthesia
Other Identifiers
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2018/1377
Identifier Type: -
Identifier Source: org_study_id
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