Effects of Red Blood Cells Transfusion on Renal Blood Flow

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

33 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-01

Study Completion Date

2022-09-01

Brief Summary

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The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound

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Detailed Description

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Conditions

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Acute Kidney Injury Transfusion-Associated Circulatory Overload Anemia Fluid Overload

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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RBC group

Patients who received RBC transfusion

Transfusion

Intervention Type OTHER

RBC transfusion (1 unit)

crystalloids group

Patients who received fluid resuscitation with crystalloids

Crystalloids infusion

Intervention Type OTHER

Infusion of 500 ml of balanced crystalloids

control group

Patients not receiving RBC nor crystalloids

No interventions assigned to this group

Interventions

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Transfusion

RBC transfusion (1 unit)

Intervention Type OTHER

Crystalloids infusion

Infusion of 500 ml of balanced crystalloids

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 and \< 90
* Hemoglobin ≥7 and ≤ 10 g/dl

Exclusion Criteria

* Ultrasound RRI evaluation non available
* Patients with arrhythmia
* Pregnancy
* Refusal to give consent
* History of renal transplantation
* Central venous access in superior vena cava not available Critical active bleeding

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No