Can Magnetic Brain Stimulation Improve Language Function in Primary Progressive Aphasia
NCT ID: NCT04193267
Last Updated: 2021-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
10 participants
INTERVENTIONAL
2020-06-01
2022-12-31
Brief Summary
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Detailed Description
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A variety of language tests will be administered to participants prior to rTMS treatment as well as following 30 sessions of daily rTMS. Additionally, language testing will be performed during the first session of rTMS treatment in order to assess the effect of simultaneous rTMS administration on language function. Performance on the pre- and post-treatment tests will be compared to determine the effect of rTMS treatment on language abilities.
Treatment will consist of daily sessions of high frequency (10 Hz) rTMS applied over the left temporal gyrus. Patients will receive one session of rTMS per day for 30 consecutive weekdays. Each session will take approximately 45 minutes to complete.
As a pilot study, this research will be used to evaluate the effect size and the feasibility of a more definitive project in the future. Both patient response and tolerability to rTMS will be analyzed.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Repetitive Transcranial Magnetic Stimulation (rTMS)
30 sessions of high-frequency (10Hz) repetitive stimulation applied over the posterior region of the left superior temporal gyrus in patients with logopenic primary progressive aphasia (PPA-L) using a MagStim Rapid2 Transcranial Magnetic Simulation machine.
MagStim Rapid2 Transcranial Magnetic Simulation
A non-invasive method of brain stimulation
Interventions
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MagStim Rapid2 Transcranial Magnetic Simulation
A non-invasive method of brain stimulation
Eligibility Criteria
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Inclusion Criteria
* Mild to moderate language impairment as assessed by the Druks and Masterson Naming Task;
* Native English speaker.
Exclusion Criteria
* History of traumatic brain injury, seizures, or another neurological disease;
* Significant medical problems (e.g. poorly controlled diabetes or hypertension or cancer within the past 5 years);
* Major depressive disorder, bipolar disorder, schizophrenia, substance use disorder or mental retardation according to the criteria of the DSM-IV;
* Any contraindication for rTMS (e.g., implanted metal devices; cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps, metal in the body \[rods, plates, screws, shrapnel, dentures, IUD\] or metallic particles in the body, surgical clips in the head, previous neurosurgery, cochlear implants, prosthetic heart valves);
* Currently pregnant or breastfeeding.
18 Years
ALL
No
Sponsors
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University of Manitoba
OTHER
Responsible Party
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Principal Investigators
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Michelle Tsang, MD
Role: PRINCIPAL_INVESTIGATOR
University of Manitoba
Mandana Modirrousta, MD PhD
Role: STUDY_DIRECTOR
University of Manitoba
Locations
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St. Boniface Hospital
Winnipeg, Manitoba, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HS23339 (B2019:108)
Identifier Type: -
Identifier Source: org_study_id
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