Effects of rTMS Based on Brain Activation During Language Performance in Stroke Patients With Non-fluent Aphasia
NCT ID: NCT02556385
Last Updated: 2022-08-31
Study Results
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Basic Information
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COMPLETED
NA
5 participants
INTERVENTIONAL
2015-10-31
2017-08-24
Brief Summary
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Detailed Description
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In the present pilot study, investigators will perform functional near-infrared spectroscopy (fNIRS) prior to rTMS treatment for selection of the most appropriate application of stimulation. Stimulation site and protocol (high frequency or low frequency rTMS) will be determined by activation pattern from the fNIRS findings with language task in individual patients.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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High frequency rTMS
Most activated area from fNIRS with language task: Perileisional Broca's area
High frequency rTMS
Most activated area from fNIRS findings: Perileisional Broca's area, High frequency rTMS (10Hz), Number of total stimuli: 800, Location: perilesional Broca's area, Intensity: 100% of resting motor threshold, Coil orientation: tangential to scalp, in combination with speech therapy(35-40min) after each rTMS session, Daily 10 treatment session
Low Frequency rTMS
Most activated area from fNIRS with language task: Contralesional homologs of Broca's area
Low frequency rTMS
Most activated area from fNIRS findings: Contralesional homologs of Broca's area, Low frequency rTMS (1Hz), Number of total stimuli: 1200, Location: Contralesional homologs of Broca's area (Pars triangularis), Intensity: 90% of resting motor threshold, Coil orientation: tangential to scalp, in combination with speech therapy(35-40min) after each rTMS session, Daily 10 treatment session
Interventions
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High frequency rTMS
Most activated area from fNIRS findings: Perileisional Broca's area, High frequency rTMS (10Hz), Number of total stimuli: 800, Location: perilesional Broca's area, Intensity: 100% of resting motor threshold, Coil orientation: tangential to scalp, in combination with speech therapy(35-40min) after each rTMS session, Daily 10 treatment session
Low frequency rTMS
Most activated area from fNIRS findings: Contralesional homologs of Broca's area, Low frequency rTMS (1Hz), Number of total stimuli: 1200, Location: Contralesional homologs of Broca's area (Pars triangularis), Intensity: 90% of resting motor threshold, Coil orientation: tangential to scalp, in combination with speech therapy(35-40min) after each rTMS session, Daily 10 treatment session
Eligibility Criteria
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Inclusion Criteria
* Right-handed
* Radiologically confirmed left hemisphere stroke
* Fluent in Korean
* First ever stroke
* More than 1 year from stroke onset
* Non-fluent (motor-dominant) aphasia
* Written informed consent
Exclusion Criteria
* Patients with traumatic brain injury
* Unable to perform the language task
* Severe cognitive impairment (MMSE less than 16)
* Skin lesion in the stimulation site of scalp
* Metal implants in the body (cardiac pacemaker or aneurysm clip)
* Pregnancy, Breastfeeding
18 Years
80 Years
ALL
No
Sponsors
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Seoul National University Bundang Hospital
OTHER
Responsible Party
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Nam-Jong Paik
Professor
Principal Investigators
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Nam-Jong Paik, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Locations
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Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital
Seongnam-si, Korea, Gyeonggi-do, South Korea
Countries
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Other Identifiers
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B-1507-308-006
Identifier Type: -
Identifier Source: org_study_id
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