Association Between Light Spectrum and Survival After Cataract Surgery

NCT ID: NCT04187157

Last Updated: 2019-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10192 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-01

Study Completion Date

2019-04-30

Brief Summary

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This study was a retrospective observational cohort analysis of subjects aged 65 years and older, who underwent bilateral cataract surgery within a single (15 hospital) healthcare system, to determine the association between type (conventional or blue-light filtering) of implanted intraocular lens and survival.

Detailed Description

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Conditions

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Cataract Age-related Cataract Circadian Rhythm Disorders Glaucoma Age Related Macular Degeneration

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Blue-light filtering intraocular lens (IOL)

Bilateral implantation of blue-filtering intraocular lens. Blue-IOL, in addition to ultraviolet, also impede the transmission of the lower visible blue spectrum between 400 and 500nm.

Blue-light filtering intraocular lens

Intervention Type DEVICE

Bilateral implantation of blue light-blocking intraocular lens

Conventional intraocular lens (IOL)

Bilateral implantation of conventional ultraviolet light-blocking intraocular lens

Conventional intraocular lens

Intervention Type DEVICE

Bilateral implantation of conventional intraocular lens

Interventions

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Blue-light filtering intraocular lens

Bilateral implantation of blue light-blocking intraocular lens

Intervention Type DEVICE

Conventional intraocular lens

Bilateral implantation of conventional intraocular lens

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* The study population consisted of all adult patients (at least 65 years) who underwent bilateral cataract surgery between January 01, 2012 and January 01, 2018 within the University of Pittsburgh Medical Center (UPMC) healthcare system. To be considered bilateral and concomitant, cataract surgery had to be performed on both the left and the right eye within a 365-day period.

Exclusion Criteria

* We excluded patients undergoing unilateral cataract surgery, surgery to replace or repair a previously implanted IOL, or bilateral implantation with one Blue-IOL and one Natural-IOL (i.e., mixed IOL transmission properties).
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Pittsburgh

OTHER

Sponsor Role lead

Responsible Party

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Matthew Rosengart

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Matthew R Rosengart, MD MPH

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

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UPMC-Presbyterian Hospital

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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PRO18060034

Identifier Type: -

Identifier Source: org_study_id

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