Immunopathologic Profiles and Blood Biomarkers in Patients With IPF

NCT ID: NCT04187079

Last Updated: 2021-08-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-18

Study Completion Date

2021-07-27

Brief Summary

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Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in patients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in patients with IPF compared with other interstitial lung diseases.

Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

Detailed Description

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Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in cryobiopsies from the lungs inpatients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in blood samples in patients with IPF compared with other interstitial lung diseases.

Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

Conditions

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Idiopathic Pulmonary Fibrosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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IPF

Patients diagnosed with idiopathic pulmonary fibrosis after multidisciplinary team discussion using medical history, HRCT pattern, laboratory findings, pulmonary function tests and cryobiopsy specimens.

No interventions assigned to this group

Other ILDs

Patients diagnosed with other interstitial diseases other than IPF after multidisciplinary team discussion using medical history, HRCT pattern, laboratory findings, pulmonary function tests and cryobiopsy specimens.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients suspected of having an ILD who are having cryobiopsies performed

Exclusion Criteria

* BMI \> 35
* DLCO \< 35%
* FVC \< 45%
* Pulmonary hypertension
* Cardiac or other severe comorbidity that will increase the risk of complications
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Venerino Poletti, Prof

Role: PRINCIPAL_INVESTIGATOR

Department of Respiratory Diaseses, Aarhus University Hospital

Locations

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Aarhus University Hospital, Department of Respiratory Diseases and Allergy

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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Cryobiopsy in IPF

Identifier Type: -

Identifier Source: org_study_id

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