Cohort of IPF Patients Experiencing an Exacerbation

NCT ID: NCT04442711

Last Updated: 2023-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-13

Study Completion Date

2028-12-31

Brief Summary

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Extension of the PFBIO cohort which includes patients with newly diagnosed idiopathic pulmonary fibrosis (IPF) for longitudinal follow-up for up to 5 years.

In the PFBIO-EXA extension, patients are included if they experience an exacerbation, or other increase in respiratory symptoms requiring hospital admission, for further collection of clinical and biological data.

Detailed Description

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The aim of this study is to investigate the diagnostic and prognostic value of clinical and blood biomarkers during exacerbations, or other increase in respiratory symptoms requiring hospital admission in patients with IPF.

Patients that are already included in the PFBIO-cohort (NCT02755441) and who are admitted to hospital with an increase in respiratory symptoms, are also included in PFBIO-EXA.

Patients are recruited within 24 hrs. from hospital admission with respiratory worsening, where clinical data, and blood samples are collected. The blood samples are investigated for the same blood biomarkers as PFBIO.

Patient related outcomes are also collected, including quality-of-life questionnaires and outcomes of the exacerbations.

Conditions

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Idiopathic Pulmonary Fibrosis

Keywords

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Exacerbation Hospitalization Biomarkers Outcome Prognosis Diagnosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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PFBIO-EXA

All patients recruited for PFBIO-EXA from the original PFBIO cohort are included into the cohort.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Admitted with an increase in respiratory symptoms
* Already included in PFBIO or included simultaneously in PFBIO and PFBIO-EXA
* Age at least 18 years

Exclusion Criteria

* Unable to provide informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Nils Hoyer

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Herlev and Gentofte Hospital

Hellerup, Copenhagen, Denmark

Site Status RECRUITING

Countries

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Denmark

Facility Contacts

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Nils Hoyer, MD PhD

Role: primary

Other Identifiers

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PFBIO-EXA

Identifier Type: -

Identifier Source: org_study_id