Immunological Characterization of Bronchoalveolar Cells in Normals

NCT ID: NCT00843414

Last Updated: 2016-07-07

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1232 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1978-03-31
• Study Completion Date: 2011-04-30

Brief Summary

To obtain the monocytes (white blood cells) from normal volunteers for the purpose of studying how proteins, fats, carbohydrates, as well as RNA and DNA for gene expression, relate to immunity. This information will be compared to other studies in patients with lung diseases such as Emphysema, Sarcoidosis, and Interstitial Pulmonary Fibrosis.

Detailed Description

To determine the functional capabilities of cells obtained from bronchoalveolar lavage fluid and peripheral blood monocytes from normal individuals. The ongoing objective varies from investigation to investigation but in general the investigational goals are to better understand the immune function of monocytes purified from normal volunteers. In some instances the emphasis will be upon comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages. This comparison is not the only goal of the study, however. In many cases the immune function of the monocyte will be sufficient in and of itself as an investigational goal. In other cases the same is true of alveolar macrophage function.

Conditions

Lung Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• healthy

Exclusion Criteria

• unable to consent

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Ohio State University

OTHER

Sponsor Role: lead

Responsible Party

Mark D. Wewers, MD

Associate Director of Pulmonary Research

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mark D Wewers, MD

Role: PRINCIPAL_INVESTIGATOR

Ohio State University

Locations

The Ohio State University

Columbus, Ohio, United States

Countries

United States

Other Identifiers

1978H0059

Identifier Type: -

Identifier Source: org_study_id