Blood Collection From Individuals With Lung Disease for Genetic Studies

NCT ID: NCT00362739

Last Updated: 2016-04-29

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 3087 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-09-30
• Study Completion Date: 2015-08-31

Brief Summary

This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, and lung cancer.

Detailed Description

The investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. The investigators aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.

Conditions

Asthma; COPD; Interstitial Lung Disease; Cystic Fibrosis; Lung Cancer

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

1: Lung Disease

Individuals with at least one of the following: (1)symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; (7) individuals suspected of history of lung diseased based on history and/or physical examination

No interventions assigned to this group

2: Normal Controls

Individuals without a history of lung disease

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Must provide informed consent
• Males and females, age 18 years and older
• Lung disease proven by at least one of the following:

• symptoms consistent with pulmonary disease
• chest X-rays consistent with lung disease
• pulmonary function tests consistent with lung disease
• lung biopsy consistent with lung disease
• family history of lung disease
• disease of organs with know associated with lung disease
• individuals suspected of history of lung disease based on history and/or physical examination
• normal controls (individuals without history of lung disease) to be sampled to provide a comparison to the lung disease cohort.

Exclusion Criteria

• Drug and/or alcohol abuse within the past six months
• Females who are pregnant or nursing

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Weill Medical College of Cornell University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ronald G Crystal, MD

Role: PRINCIPAL_INVESTIGATOR

The New York Presbyterian Hospital -- Weill Medical College of Cornell University

Locations

New York Presbyterian Hospital -- Weill Cornell Medical College of Cornell University

New York, New York, United States

Countries

United States

Other Identifiers

0508008095

Identifier Type: -

Identifier Source: org_study_id