Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
67 participants
OBSERVATIONAL
2009-06-30
2011-03-31
Brief Summary
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Detailed Description
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To study this hypothesis, we have two specific aims:
1. To evaluate plasma MIF concentration as a marker of severity in ILD and PH and
2. To determine the utility of breathe condensate analysis in the evaluation of ILD and PH. If we are successful in identifying MIF as a biomarker, it may identify MIF as a useful therapeutic target, as we have shown in other inflammatory disorders.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Healthy Controls
Subjects are made up of healthy adults
Blood Gas
Subject will have both venous and arterial blood draws to assess for the bloods content of MIF
Pulmonary Exercise Test
Subject will ride exercise bike to assess their pulmonary function level.
Spirometry
To assess subjects lung function
Breath Condensate Collector
Subject with use breathing apparatus to allow researchers to collect breath condensate to assess level of MIF in breathe condensate.
Affected
Subjects have Pulmonary Hypertension
Blood Gas
Subject will have both venous and arterial blood draws to assess for the bloods content of MIF
Pulmonary Exercise Test
Subject will ride exercise bike to assess their pulmonary function level.
Spirometry
To assess subjects lung function
Breath Condensate Collector
Subject with use breathing apparatus to allow researchers to collect breath condensate to assess level of MIF in breathe condensate.
Interventions
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Blood Gas
Subject will have both venous and arterial blood draws to assess for the bloods content of MIF
Pulmonary Exercise Test
Subject will ride exercise bike to assess their pulmonary function level.
Spirometry
To assess subjects lung function
Breath Condensate Collector
Subject with use breathing apparatus to allow researchers to collect breath condensate to assess level of MIF in breathe condensate.
Eligibility Criteria
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Inclusion Criteria
* Subject has confirmed Pulmonary Hypertension and Interstitial Lung Disease
* Subject are able to complete study procedures, such as spirometry, and Pulmonary Exercise test.
Exclusion Criteria
* Subject is unable to perform tasks associated with study
18 Years
ALL
Yes
Sponsors
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Northwell Health
OTHER
Responsible Party
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North Shore LIJ Health System
Principal Investigators
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Arunabh Talwar, M.D.
Role: PRINCIPAL_INVESTIGATOR
Northwell Health
Ed Miller, Ph.D
Role: PRINCIPAL_INVESTIGATOR
North Shore Long Island Jewish Healthy System
Locations
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Interstitial Lung Disease and Pulmonary Hypertension Programs
New Hyde Park, New York, United States
Countries
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Other Identifiers
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GCRC 0274
Identifier Type: -
Identifier Source: org_study_id
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