Role of Fibrocytes in the Bronchial Remodelling of Chronic Obstructive Pulmonary Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-10

Study Completion Date

2016-05-20

Brief Summary

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Airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. It also influences the prognosis of Chronic Obstructive Pulmonary Disease (COPD) and its mechanisms remain largely unknown. The role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. However, the recruitment of blood fibrocytes and their involvement in COPD airway remodelling remain unknown.

The main objective of the study is to analyse the distribution and quantify the number of the peri-bronchial and blood circulating fibrocytes in patients with different stages of COPD compared to control subjects.

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Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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COPD

15 patients with COPD from 1 to 4 according to the GOLD 2011

No interventions assigned to this group

Non smoker Control

15 patients without COPD and no smoking history

No interventions assigned to this group

Smoker Control

15 patients without COPD but a smoking history

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Male or female aged more than 40 yr
* Patient needed a thoracic surgery such as lobectomy for cancer or lung transplantation or lung reduction volume surgery.
* COPD group: diagnostic of COPD and differentiation of the stage from 1 to 4 according to the GOLD guidelines.
* Control group: subjects with normal lung function testing and no chronic symptoms (cough or expectoration). Subjects will be separated in 2 groups according to smoking history (Never smokers, smokers (former or current) and paired to patients according to age and sex.
* with a written informed consent

Exclusion Criteria

* Subject without any social security or health insurance
* Asthma, lung fibrosis or idiopathic pulmonary hypertension
* Chronic viral infections (hepatitis, HIV)
* Pregnant woman or breastfeeding
* Subject included for cancer surgery with a Pn0 diagnosis not confirmed after the intervention.

Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No