Pulmonary Fibrosis and Telomerase Mutation Study

NCT ID: NCT01501578

Last Updated: 2018-02-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

81 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-12-31

Study Completion Date

2015-12-31

Brief Summary

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This study is an observational and retrospective study of patients with pulmonary fibrosis associated or not with telomerase mutation.

The purpose of this study is to describe in detail the cases with telomerase mutation in terms of features on CT scan, respiratory function and evolution, in comparison to control subjects with idiopathic pulmonary fibrosis and no telomerase mutation identified or family history.

Detailed Description

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Two "control" subjects will be enrolled for one subject with telomerase mutation.

The data are all the results of investigations conducted for the diagnosis of idiopathic pulmonary fibrosis and during routine follow up of patients.

The CT scans will reviewed centrally to homogenize the description.

Conditions

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Pulmonary Fibrosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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telomerase mutation

Patients with interstitial lung disease and telomerase mutation

No interventions assigned to this group

control

Patients with idiopathic pulmonary fibrosis and without telomerase mutation

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Diffuse interstitial lung disease on CT scan
* Telomerase mutation analysis

Exclusion Criteria

* Presence of connective tissue disease, or pneumoconiosis or drug induced lung disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bichat Hospital

OTHER

Sponsor Role collaborator

Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires

OTHER

Sponsor Role lead

Responsible Party

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Vincent COTTIN

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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vincent Cottin, MD

Role: PRINCIPAL_INVESTIGATOR

Hospices civils de Lyon / University Lyon I

Locations

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Louis Pradel Hospital (Bâtiment A4)

Lyon, , France

Site Status

Countries

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France

Related Links

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http://maladies-pulmonaires-rares.fr/

website National French Reference Center for rare lung diseases

Other Identifiers

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GERMOP-004

Identifier Type: -

Identifier Source: org_study_id

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