Repair, Remodeling and Regeneration of the Bronchial Epithelium of COPD Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-17

Study Completion Date

2018-04-17

Brief Summary

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COPD is characterized by exagerated decline FEV1 related to obstructive non reversible airflow. This could be the consequence of structural changes and inflammatory pattern of the bronchial wall. Lesions could lead to normal but also abnormal remodeling specially in COPD including a decrease in Club cells number and function.There is no treatment actually available targeted to a normal repair of the epithelium. The objective of this work is to identify potential targets for reprograming bronchial epithelial cells I order to achieve a good repair.

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Detailed Description

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Conditions

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Heathy Volunteers Smokers COPD

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Heathy volunteers, smokers and COPD

Group Type EXPERIMENTAL

In vitro experiments on bronchial epithelial cells

Intervention Type OTHER

Interventions

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In vitro experiments on bronchial epithelial cells

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

COPD - Smokers or ex smokers \> 30p/yr

* FEV1/FVC \< 0.7
* With a fibroscopy prescription

Smokers - Smokers or ex smokers \> 30p/yr

* FEV1/FVC \> 0.7
* With a fibroscopy prescription

Controls - age superior or equal to 18

* no smoker (for 5 years)
* with a fibroscopy prescription