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Evaluation of Reactive Oxygen Metabolites in the Value of COPD

NCT ID: NCT02297633

Last Updated: 2014-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

320 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-10-31

Study Completion Date

2017-07-31

Brief Summary

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This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.

Detailed Description

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Reactive oxygen metabolites (reactive oxygen metabolites, ROMs) test is a method by measuring the total reactive oxygen metabolites (ROMs) content in blood so as to evaluate the overall level of oxidative stress in the human body .Our previous studies have established the method of detecting ROMs which is suitable for fully automatic biochemical analyser.Our study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.

Conditions

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COPD(Chronic Obstructive Pulmonary Disease)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Stability in patients with COPD

Those patients diagnosed COPD according to the GOLD guideline and without acute exacerbation within one month.

No interventions assigned to this group

AECOPD

the diagnosis of an exacerbation relies exclusively on the clinical presentation of the patient complaining of an acute change of symptoms (baseline dyspnea, cough, and/or sputum production) that is beyond normal day-to-day variation.

No interventions assigned to this group

Healthy persons without smoking

The healthy people who do not smoke

No interventions assigned to this group

Healthy persons with smoking

Healthy persons who smoke

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of COPD according to GOLD 2013

Exclusion Criteria

* A history of asthma or other chronic lung diseases Take Antioxidant therapy There are new or recurrent symptomatic myocardial ischemia, severe arrhythmia, cardiac insufficiency cerebrovascular disease Senile dementia or cognitive impairment cancer Severe liver and kidney and other viscera function insufficiency Language communication barriers Limb activity disorder The last 3 months participated in sports training
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Beijing Chao Yang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jie liu

Resident

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ting Yang, Doctor

Role: STUDY_DIRECTOR

Respiratory Institute, Beijing chaoyang hospital

Locations

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Respiratory Institute;Beijing chaoyang hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Ting Yang, Doctor

Role: CONTACT

[email protected]
13651380809

Jie Liu, Master

Role: CONTACT

[email protected]
18811225394

Facility Contacts

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Ting Yang, Doctor

Role: primary

[email protected]
13651380809

Jie Liu, Master

Role: backup

[email protected]
18811225394

Other Identifiers

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BJCYYT-12345

Identifier Type: -

Identifier Source: org_study_id