Role of Fibrocytes in Chronic Obstructive Pulmonary Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

115 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-03-11

Study Completion Date

2016-05-31

Brief Summary

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Chronic obstructive pulmonary disease (COPD) is a frequent airway disease characterized by both bronchial inflammation and remodelling.

Bronchial mucosa is infiltrated by macrophages, neutrophils and lymphocytes. In addition, the number of eosinophils can be also increased during exacerbation.

Airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. It also influences the prognosis of COPD and its mechanisms remain largely unknown. The role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. However, the recruitment of blood fibrocytes and their involvement in COPD airway remodelling remain unknown.

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Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Chronic obstructive pulmonary disease patients

COPD patients with exacerbation will be recruited during hospitalization in Intensive care unit or as outpatients in the clinical investigation centre of the CHU de Bordeaux.

Inclusion visit: blood sample for fibrocytes analysis. Second visit 2 months ± 7 days after the exacerbation: clinical and functional evaluation (plethysmography, TLCO, arterial gaz), blood sample for fibrocytes analysis.

blood sample

Intervention Type PROCEDURE

blood sample for fibrocytes analysis

Clinical and functional evaluation

Intervention Type PROCEDURE

Plethysmography, Carbon monoxide capacity of transfer , arterial gaz

Control group

Subjects without any history of lung disease and with normal lung function testing

blood sample

Intervention Type PROCEDURE

blood sample for fibrocytes analysis

Interventions

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blood sample

blood sample for fibrocytes analysis

Intervention Type PROCEDURE

Clinical and functional evaluation

Plethysmography, Carbon monoxide capacity of transfer , arterial gaz

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients: diagnostic of Chronic obstructive pulmonary disease (COPD) exacerbation.
* Control group: subjects without any history of lung disease and with normal lung function testing. Subjects will be separated in 2 sub-groups according to smoking history (Never smokers, smokers (former or current) and paired to patients according to age and sex.
* Written informed consent

Exclusion Criteria

* Subject without any social security or health insurance
* Asthma, lung fibrosis or idiopathic pulmonary hypertension
* Chronic viral infections (hepatitis, HIV)

Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes