Age and Number of Previous Anesthesia on the Development of Mild Cognitive Decline (MCI)
NCT ID: NCT04182477
Last Updated: 2023-11-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
168 participants
OBSERVATIONAL
2019-01-07
2023-09-15
Brief Summary
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It has been related to age and comorbilities, but the linkage between MCI and number of previous anesthesia is still unclear.
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Detailed Description
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For the diagnosis of MCI, the core clinical criteria are: concern about a change in cognition, impairment in one or more cognitive domains, preservation of independence in functional abilities and no presence of dementia.
The Montreal Cognitive Assessment (MoCA), a test that was developed specifically for detection of MCI, has a sensitivity of 80 to 100% and specificity of 50 to 76% using a cut-off point of 25 to make diagnosis, and it has been suggested that it is better than Mini Mental Status Evaluation (MMSE) in accurately differentiating individuals with MCI from those with normal cognition.
Various risk factors have been proposed for MCI, in particular the role of multiple biological, behavioural, social and environmental factors have been investigated.
Of them, increasing in age, lower educational level, sleep-disordered breathing and vascular risk factors (e.g. diabetes and hypertension) seem to be the most important.
It has been estimated that MCI is itself a risk factor both for dementia (it converts to dementia at a rate of 10% per year, for delirium and Post-Operative Cognitive Decline (POCD).
Hence, this study aims to investigate the incidence of MCI in cardiac-surgery adult patients, enlisted for Coronary Artery By-Pass Grafting (CABG) or Valve Surgery, and to investigate the role of previous general anaesthesia in anamnesis as a risk factor for MCI evenience.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with at least one general anesthesia in anamnesis
Patients who underwent during their life at least one anesthesia in anamnesis
Montreal Cognitive Assessment
Neuro-cognitive test evaluating general mental status and performance
Patient without general anesthesia in anamnesis
Patients who never underwent general anesthesia during their life
Montreal Cognitive Assessment
Neuro-cognitive test evaluating general mental status and performance
Interventions
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Montreal Cognitive Assessment
Neuro-cognitive test evaluating general mental status and performance
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
99 Years
ALL
No
Sponsors
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Eleonora Maran
UNKNOWN
Alessandro de Laurenzis
UNKNOWN
University of Padova
OTHER
Responsible Party
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Federico Linassi
MD, Principal investigator
Locations
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Azienda Ospedaliera di Padova
Padua, , Italy
Countries
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Other Identifiers
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ZivagoMCI
Identifier Type: -
Identifier Source: org_study_id
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