The Ecological Role of Yeasts in the Human Gut

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-09-23

Study Completion Date

2021-09-23

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) (categorised into Crohn's disease (CD) and ulcerative colitis (UC)) are chronic gut disorders with debilitating symptoms that profoundly impact quality of life, healthcare systems and the economy through lost work days. IBS is common with a prevalence of up to 22%, whereas IBD has a prevalence of 0.3% for CD and 0.5% for UC in Europe. Despite a suggested immunological and genetic aspect of IBD, the causes of IBS and IBD are unknown, however, both have been linked to yeasts in the gut.

Due to their lower abundance (constituting only around 0.1% of the total microorganisms in the gut) yeasts have been less studied than bacteria. More recently, significantly altered diversity and composition of yeasts have been identified in IBS and IBD but further investigation is required to fully develop the role of yeasts in the gut.

This observational study will assess yeasts and their function in the gut, comparing diseased subjects with healthy controls. The overall aim is to determine if yeasts could be targeted as a potential therapeutic for IBS and IBD to provide relief to sufferers as well as reducing the burden on healthcare systems.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Role of Intestinal Inflammation in Irritable Bowel Syndrome (IBS)

NCT01072903

Inflammation Colon, Irritable Colonic Diseases, Functional +1 more

COMPLETED

The Stool Microbiome of Treated and Untreated IBS (Irritable Bowel Syndrome) Patients

NCT05972317

Irritable Bowel Syndrome

RECRUITING NA

Effects of Faecal Microbiota Transplantation in Patients With IBS

NCT03822299

Irritable Bowel Syndrome

COMPLETED NA

Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome

NCT01632488

Irritable Bowel Syndrome Inflammatory Bowel Disease

UNKNOWN

Endomicroscopy, IBS and Food Intolerance

NCT01692613

Endomicroscopy Inflammatory Bowel Syndrome Food Intolerance

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Irritable Bowel Syndrome Inflammatory Bowel Diseases Gastrointestinal Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy

Healthy participants are those without IBS, IBD or any other gastrointestinal disorder

No interventions assigned to this group

Irritable bowel syndrome (IBS)

Participants with Rome IV diagnosed IBS

No interventions assigned to this group

Inflammatory bowel disease (IBD)

Patients with IBD - either ulcerative colitis (UC) or Crohn's disease (CD)

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Aged 20-60 years old.
* Either healthy or diagnosed with a gut disorder: Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD) which may include Crohn's disease or ulcerative colitis.
* In good general health.
* Provided written informed consent and willing to participate in this study.

Exclusion Criteria

* Received antibiotics in the previous six months.
* Consume prebiotics or probiotics on a regular basis (at least 3 times per week) in the last 2 weeks or intend to throughout the course of the study. (Examples of these include: Multibionta multivitamins, Danone Actimel yoghurt drink; Danone Activia yoghurt; Yakult fermented milk drink; Kellogg's Rice Krispies multigrain and Muller Vitality yoghurts/drinks).
* Current use of immunosuppressive drugs.
* Use of other medication which affects gastrointestinal motility and/or gut discomfort.
* History of alcohol or drug misuse.

Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes