Effects of Autogenous Dentin Graft on Socket Preservation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-12-05

Study Completion Date

2018-08-27

Brief Summary

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Various graft materials are used to reconstruct bone defects in the jaws due to tooth loss, trauma, advanced periodontal diseases, pathological lesions and congenital disorders. The main features of an ideal bone graft are osteogenesis, osteoinduction and osteoconduction. Autogenous bone graft is considered as the gold standard among all bone graft materials. Because it has all the features that an ideal bone graft should have. However, there are some disadvantages such as donor site morbidity, obtaining limited amounts and high rates of resorption. Because of these disadvantages, other bone graft materials such as allografts, xenografts and alloplastic bone grafts are frequently used for bone augmentation. In the light of recent studies, the limits of conventional bone graft materials such as limited osteoconduction capacity and disease transmission have been clearly demonstrated. Due to the disadvantages of these materials, studies are directed to develop alternative graft materials. Aim of this study is to analyse the effects of autogenous dentin graft and mixture of autogenous dentin graft and platelet rich fibrin (PRF) applied to the tooth extraction sockets on bone healing process. A total of 57 extraction sockets in 9 patients who were planned to be treated with dental implant after tooth extraction were evaluated in this study. Extraction sockets were divided randomly into 3 groups. In the first group, sockets were filled with autogenous dentin graft (Group D-20 sockets). In the second group, sockets were filled with the mixture of PRF and autogenous dentin graft (Group DP-21 sockets). In the third group, sockets were left empty as control group (Group C-16 sockets). After 3 months, histological and immunohistochemical evaluations were performed on the samples taken during the implant surgery. Additionally, samples obtained from each group were examined by scanning electron microscopy (SEM).

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Detailed Description

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Conditions

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Bone Regeneration Bone And Bones Bone Substitutes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

Extraction sockets with spontaneous healing (16 sockets).

Group Type NO_INTERVENTION

No interventions assigned to this group

Dentin

Extraction sockets were filled with undemineralized autogenous dentin graft (20 sockets).

Group Type ACTIVE_COMPARATOR

autogenous dentin graft

Intervention Type BIOLOGICAL

Dentin+PRF

Extraction sockets were filled with mixture of undemineralized autogenous dentin graft and platelet rich fibrin (PRF) (21 sockets).

Group Type ACTIVE_COMPARATOR

autogenous dentin graft

Intervention Type BIOLOGICAL

platelet rich fibrin (PRF)

Intervention Type BIOLOGICAL

Interventions

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autogenous dentin graft

Intervention Type BIOLOGICAL

platelet rich fibrin (PRF)

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Age≥18 years,
* Systemically healthy patients (ASA I and II),
* Adequate restorative space for implant-retained restoration.

Exclusion Criteria

* Teeth with deep decay or root canal filling,
* Systemically complicated patients (ASA III, IV, V),
* Presence of acute infection,
* Pregnancy or lactation,
* Unwillingness to return for the follow-up periods

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes