Group Culture May Affect Embryo Quality in Assisted Reproduction Technology
NCT ID: NCT04011319
Last Updated: 2019-07-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
2000 participants
INTERVENTIONAL
2019-04-01
2020-03-31
Brief Summary
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Detailed Description
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In this study, zygotes derived from sibling oocytes were randomized 1:1 to either the microwell group culture (experiment group) or conventional droplet culture (control group). In experiment group, 4 zygotes cultured in a new special microwell (120 μl droplet were divided into 4 areas) with a corral dish (EMBC-010, LifeGlobal), embryos can communicate with each other in the same culture environment. In control group, single embryo individually cultured in a droplet (60 μl). Embryos were cultured in specific desktop three-gas incubators (COOK) of 37°C, 6% CO2 (carbon dioxide) , 5% O2 and 89% N2, and scored according to the criteria described in the ESHRE-ALPHA consensus. Consequently, exploitable embryos rate, good embryo quality, blastocyst formation rate were recorded. Other relevant parameters such as clinical pregnancy, live-birth or miscarriage were also recorded to evaluate the outcomes. Proper culture conditions can result in superior embryo viability, this research intends to discuss whether group culture can improve the embryo quality and clinical outcomes in ART.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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convention culture
Each droplet separate culturing an individual embryo.
No interventions assigned to this group
group culture
Embryos were cultured in the same droplet.
group culture
Four embryos were cultured in the same droplet by a special dish.
Interventions
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group culture
Four embryos were cultured in the same droplet by a special dish.
Eligibility Criteria
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Inclusion Criteria
* Number of oocytes≥ 8.
Exclusion Criteria
* The number of normal fertilized zygotes less than 4.
22 Years
40 Years
FEMALE
Yes
Sponsors
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Tang-Du Hospital
OTHER
Responsible Party
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Principal Investigators
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Bo Li
Role: STUDY_DIRECTOR
Tang-Du Hospital
Locations
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Tangdu Hospital
Xi'an, Shaanxi, China
Countries
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Central Contacts
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Facility Contacts
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Ming Wang
Role: primary
Other Identifiers
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GCIEQ
Identifier Type: -
Identifier Source: org_study_id
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