Relationship Between Exposure to Phenols and Pregnancy Outcomes After Embryo Transfer

NCT ID: NCT06767202

Last Updated: 2025-07-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-03-14
• Study Completion Date: 2025-07-01

Brief Summary

The goal of this observational study is to explore the association between phenol exposure and pregnancy outcome after embryo transfer. The main question it aims to answer [is/are]:

Whether exposure to phenols is associated with adverse pregnancy outcomes in pregnant women undergoing assisted reproductive technology?

Detailed Description

First of all, paper questionnaires were used in this study, including general information questionnaire, health effect questionnaire, health survey summary form, and dietary assessment questionnaire. Secondly, obtain the relevant information of the medical record system, including: assisted reproduction protocol, IVF examination results, B-ultrasound examination results, laboratory test indicators, pregnancy outcome information and newborn information. Finally, urine samples were detected using a high performance liquid chromatography mass spectrometer.

Conditions

Embryo Transfer

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Pregnant women undergoing assisted reproductive technology in Tongji Hospital, Wuhan City, Hubei Pro

1. Chinese citizens over the age of 20;

2. IVF/ICSI assisted reproductive treatment in our center;

3. Complete clinical data, reproductive outcomes and questionnaire data of both sexes;

4. Knowing about this research and voluntarily accepting this research;

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Chinese citizens over the age of 20;

2. IVF/ICSI assisted reproductive treatment in our center;

3. Complete clinical data, reproductive outcomes and questionnaire data of both sexes;

4. Knowing about this research and voluntarily accepting this research;

Exclusion Criteria

1. The patient receives sperm or egg donation treatment;

2. The patient gave up the egg collection operation due to various reasons, and the cycle was canceled;

3. The patient abandons treatment before achieving clinical pregnancy, but the fertile frozen embryo is not transferred;

4. There are contraindications to pregnancy, such as serious liver and kidney diseases, malignant tumors, serious mental diseases, uncorrected coagulation function abnormalities or endocrine indicators abnormalities;

5. Incomplete or missing clinical data or follow-up data;

• Minimum Eligible Age: 20 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

keqin liu

OTHER

Sponsor Role: lead

Responsible Party

keqin liu

Principal Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Reproductive center，tongji hospital，huazhong university of science and technology

Wuhan, Hubei, China

Countries

China

Other Identifiers

liukeqin0208

Identifier Type: -

Identifier Source: org_study_id