Comparison of Individual Culture and Group Culture of Preimplantation Embryos in Human IVF Treatments

NCT ID: NCT01774006

Last Updated: 2015-09-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

532 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-09-30

Study Completion Date

2015-09-30

Brief Summary

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Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in group culture using WOW (well of the well) petridish.

Primary outcome: implantation and pregnancy rates Secondary outcome: fertilization rate and embryo quality

Detailed Description

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Conditions

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Other Complications Associated With Artificial Fertilization

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group culture

Embryos cultured in groups of 2-10

individual embryo culture or group culture

Intervention Type OTHER

Embryos cultured in a 25 microliter droplet of culture media individually in a conventional petridish or in groups of 2-10 embryos in a Well-of-the-Well petridish

Individual culture

Embryos cultured individually

individual embryo culture or group culture

Intervention Type OTHER

Embryos cultured in a 25 microliter droplet of culture media individually in a conventional petridish or in groups of 2-10 embryos in a Well-of-the-Well petridish

Interventions

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individual embryo culture or group culture

Embryos cultured in a 25 microliter droplet of culture media individually in a conventional petridish or in groups of 2-10 embryos in a Well-of-the-Well petridish

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Infertile patients entering in vitro fertilization treatment
* at least 1 oocyte collected

Exclusion Criteria

* no oocytes collected
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Semmelweis University

OTHER

Sponsor Role lead

Responsible Party

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Peter Fancsovits, Ph.D.

Senior Clinical Embryologyst

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Janos Urbancsek, DSc

Role: PRINCIPAL_INVESTIGATOR

Semmelweis University First Department of Obstetrics and Gynecology

Peter Fancsovits, Ph.D.

Role: STUDY_CHAIR

Semmelweis University First Department of Obstetrics and Gynecology

Csaba Pribenszky, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Veterinary Sciences, Budapest

Adam Lehner, MSc

Role: PRINCIPAL_INVESTIGATOR

Semmelweis University First Department of Obstetrics and Gynecology

Locations

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Semmelweis University First Department of Obstetrics and Gynecology

Budapest, , Hungary

Site Status

Countries

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Hungary

References

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Fancsovits P, Pribenszky C, Lehner A, Murber A, Kaszas Z, Nemes A, Urbancsek J. Prospective-randomized study comparing clinical outcomes of IVF treatments where embryos were cultured individually or in a microwell group culture dish. Biol Futur. 2022 Jun;73(2):229-236. doi: 10.1007/s42977-022-00113-8. Epub 2022 Mar 12.

Reference Type DERIVED
PMID: 35278201 (View on PubMed)

Other Identifiers

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SemmelweisU-001

Identifier Type: -

Identifier Source: org_study_id

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