Embryo Development in Microfluidics System of Culture

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2011-10-31

Brief Summary

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Embryo culture is a cornerstone of in vitro fertilization treatments. Usually, embryos are cultured in microdrops of culture media in incubators with controlled temperature, humidity and atmosphere. However, these culture systems are static, while in vivo the initial growth of the embryo takes place in the uterine tube and they are submitted to a dynamic environment. The aim of this study is to compare the embryo development on days 2 and 3 of culture morphological features of embryos under static and dynamic(microfluidics) systems of culture.

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Detailed Description

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Embryo culture is a cornerstone of in vitro fertilization treatments. Usually, embryos are cultured in microdrops of culture media in incubators with controlled temperature, humidity and atmosphere. However, these culture systems are static, while in vivo the initial growth of the embryo takes place in the uterine tube and they are submitted to a dynamic environment. The aim of this study is to compare the embryo development on days 2 and 3 of culture morphological features of embryos under static and dynamic(microfluidics) systems of culture.

Conditions

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Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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Static culture

Embryos individually cultured in microdrops of 40 microliters of G-IVFplus series V

Group Type ACTIVE_COMPARATOR

Static culture

Intervention Type DEVICE

Embryos cultured in 40 microliters microdrops of G-IVF plus series V

Smart plataform

Embryos culture in dynamics microfluidic culture system

Group Type EXPERIMENTAL

SMART dynamic system of embryo culture

Intervention Type DEVICE

Embryos will be cultured in a dynamic system of microfluidics.

Interventions

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SMART dynamic system of embryo culture

Embryos will be cultured in a dynamic system of microfluidics.

Intervention Type DEVICE

Static culture

Embryos cultured in 40 microliters microdrops of G-IVF plus series V

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age between 21 and 35 years old
* No more than 1 previous IVF failure
* Absence of physical conditions that can interfere in oocyte quality
* At least 8 zigotes 24 hours after fertilization