Changes in Reliability When Assessing Multiple Patient-Reported Outcome Measures

NCT ID: NCT04008680

Last Updated: 2021-07-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-17

Study Completion Date

2022-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study investigates how reliability of patient reported outcomes can be affected with questionnaire burden and and the number of questionnaires given to study participants.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The primary objective of the study is to determine if the number of remotely administered questionnaires completed by fracture patients affects the psychometric properties of a questionnaire itself. We will assess the internal consistency of the EuroQuol Five Dimension - Five Level (EQ-5D-5L) Health Survey questionnaire as more questionnaires are applied.

The secondary objective is to evaluate how the number of questionnaires and the time it takes to complete them impact patient's preferences and values. We will measure the time taken by each participant to complete the EQ-5D-5L questionnaire to evaluate if it changes meaningfully as the number of questionnaires given to participants' increases. Additionally, we will assess patient preferences and values by asking how well the remotely collected PROMs reflect their health status, and how this changes relative to the number of questionnaires administered.

Our hypothesis is that there is a progressive decline in psychometric properties in the EQ-5D-5L, both in reliability and validity, as we increase the number of questionnaires given to participants. We also hypothesize that the time to complete the ED-5D-5L will increase as the number of questionnaires given to participants' increases, and that there is a threshold at which the patient feels there are no additional value to completing additional remote PROMS to adequately reflect their health status.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

PROM

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

4 group randomized clinical trial
Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Low response burden

Participants will be assigned to complete only the EQ-5D-5L questionnaire.

Group Type OTHER

EQ-5D-5L survey internal consistency

Intervention Type OTHER

To see how increasing the number of questionnaires affects the internal consistency of the EQ-5D-5L.

Low to medium response burden

Participants will be assigned to complete the General Anxiety Disorder-7 (GAD-7) questionnaire first, followed by the EQ-5D-5L questionnaire.

Group Type OTHER

EQ-5D-5L survey internal consistency

Intervention Type OTHER

To see how increasing the number of questionnaires affects the internal consistency of the EQ-5D-5L.

Medium to high response burden

Participants will be assigned to complete the Pain Catastrophizing Scale (PCS) questionnaire first, followed by the GAD-7, and lastly the EQ-5D-5L questionnaire.

Group Type OTHER

EQ-5D-5L survey internal consistency

Intervention Type OTHER

To see how increasing the number of questionnaires affects the internal consistency of the EQ-5D-5L.

High response burden

Participants will be assigned to complete the Brief Pain Inventory (BPI) questionnaire first, followed by the PCS secondly, the GAD-7 third, and lastly the EQ-5D-5L questionnaire.

Group Type OTHER

EQ-5D-5L survey internal consistency

Intervention Type OTHER

To see how increasing the number of questionnaires affects the internal consistency of the EQ-5D-5L.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

EQ-5D-5L survey internal consistency

To see how increasing the number of questionnaires affects the internal consistency of the EQ-5D-5L.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. The patient presents to the in-person or virtual fracture clinic for his/her own appointment.
2. The patient has a fracture that is being managed either operatively or non-operatively.
3. Fracture occurred in the past 6 months.
4. The patient is 18 years of age or older.
5. The patient is able to read, understand, and write in English.
6. Patient provides informed, verbal or written consent.

Exclusion Criteria

1. The patient is considered too ill or injured to participate in the study.
2. The patient is cognitively impaired, intoxicated or otherwise unable to provide consent or participate in the study.
3. The patient is co-enrolled in another study requiring completion of multiple additional PROMs.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hamilton Health Sciences Corporation

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Francesc Antoni Marcano-Fernandez, PhD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Herman Johal, MD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Hamilton Health Sciences - General Site

Hamilton, Ontario, Canada

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Canada

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Gina Del Fabbro, BPH

Role: CONTACT

2898080709

Carlos Prada

Role: CONTACT

6477818694

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Gina Del Fabbro, BPH

Role: primary

2898080709

Jodi Gallant

Role: backup

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

HiREB 7607

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Study on Outcomes of Proximal Humerus Fractures
NCT07060664 NOT_YET_RECRUITING NA