Connectomics in Psychiatric Classification

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-01

Study Completion Date

2019-09-05

Brief Summary

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Washington University Early Recognition Center is conducting a research study to examine brain functional connectivity and network patterns in participants with dementia.

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Detailed Description

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This study extends the assessment of brain connectivity and function, being conducted in the Human Connectome Project (HCP), to psychiatrically ill populations. The HCP consortium has made significant improvements in MRI instrumentation, data acquisition, preprocessing, and analysis. These improvements are currently providing publicly available data on the structure, function, and connectivity of young adult human (age 22-35) brains at unprecedented spatial resolution, temporal resolution, and accuracy. This study will focus on individuals aged 45-85 years who have a diagnosis of dementia, or are healthy controls. Additionally, similar to the HCP, the investigator will study the effect of genetics on the patterns of brain connectivity in various psychiatric populations. DNA will be collected non-invasively from saliva. Furthermore, this investigator will study cortisol levels in hair samples as an additional assessment to help characterize brain imagining findings.

Conditions

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Dementia Dementia Alzheimers Frontotemporal Dementia Pick's Disease With Dementia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control

Individuals between 45-85 years old with no diagnosis of dementia. No intervention used

MRI Brain Imaging

Intervention Type DEVICE

Up to two Magnetic Resonance Imaging (MRI) scan sessions will be done, altogether totaling just under 3 hours of scanning. MR scanners measure brain anatomy and activity using very strong magnets. No X-rays or radiation are involved.

Mental Health Assessment and Computerized Cognitive Test

Intervention Type BEHAVIORAL

Participants will be asked to complete questionnaires and will be asked questions that address a broad range of personal life experiences involving social, occupational, domestic, and other behaviors.

Dementia

Individuals between 45-85 years old with a diagnosis of dementia. No intervention used

MRI Brain Imaging

Intervention Type DEVICE

Up to two Magnetic Resonance Imaging (MRI) scan sessions will be done, altogether totaling just under 3 hours of scanning. MR scanners measure brain anatomy and activity using very strong magnets. No X-rays or radiation are involved.

Mental Health Assessment and Computerized Cognitive Test

Intervention Type BEHAVIORAL

Participants will be asked to complete questionnaires and will be asked questions that address a broad range of personal life experiences involving social, occupational, domestic, and other behaviors.

Interventions

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MRI Brain Imaging

Up to two Magnetic Resonance Imaging (MRI) scan sessions will be done, altogether totaling just under 3 hours of scanning. MR scanners measure brain anatomy and activity using very strong magnets. No X-rays or radiation are involved.

Intervention Type DEVICE

Mental Health Assessment and Computerized Cognitive Test

Participants will be asked to complete questionnaires and will be asked questions that address a broad range of personal life experiences involving social, occupational, domestic, and other behaviors.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Ages 45-85
* Has consented to participate or has an LAR present that has consented to participate
* DSM-5 diagnosis of Dementia

Exclusion Criteria

* Any genetic disorder, such as cystic fibrosis or sickle cell disease
* Multiple Sclerosis
* Cerebral Palsy
* Loss of consciousness for \>30 minutes
* Pregnancy
* Hospitalization for stroke, brain aneurysm, brain hemorrhage, or subdural hematoma

Minimum Eligible Age

45 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes