A Study the Population Pharmacokinetics of Children of Infectious Disease in Central Nervous System
NCT ID: NCT03960905
Last Updated: 2019-05-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
800 participants
OBSERVATIONAL
2019-01-01
2020-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Children with the usage of anti-infective drugs
in conformity with the clinical practice
Children with the usage of anti-infective drugs
According to the models of population pharmacokinetics,the investigators and want to correlate use of antibiotics with treatment effectiveness and safety in children.
Interventions
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Children with the usage of anti-infective drugs
According to the models of population pharmacokinetics,the investigators and want to correlate use of antibiotics with treatment effectiveness and safety in children.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Clinical symptoms: acute onset, fever (axillary temperature 38 ℃ or higher), headache, altered level of consciousness, vomiting, irritability, sleepiness, low muscle tone, seizures, before the fontanelle full or uplift, positive meningeal stimulation;
* Aboratory examination: CSF appearance change, CSF routine WBC \>100 per ml, CSF routine WBC 10-100 per ml, glucose \<40mg/dl, protein \>100mg/dl), positive detection of etiology (bacterial culture, antigen detection, gram staining).
Exclusion Criteria
* central nervous system infection complicated with tumor;
* allergic to carbapenems or glycopeptide antibiotics;
* other cases not suitable for enrollment (small sample size, incomplete clinical data, etc.).
29 Days
18 Years
ALL
No
Sponsors
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Beijing Children's Hospital
OTHER
Wei Zhao
OTHER
Responsible Party
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Wei Zhao
Professor; Head of department of clinical pharmacy and pharmacology
Locations
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Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2019-CNSI-001
Identifier Type: -
Identifier Source: org_study_id
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