Pharmacokinetics of Antibiotics During Extracorporeal Membrane Oxygenation (ECMO) Support

NCT ID: NCT03922451

Last Updated: 2022-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

4 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-27

Study Completion Date

2022-02-28

Brief Summary

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This study will measure plasma concentrations of piperacillin-tazobactam and cefazolin in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to better understand the pharmacokinetics of these medications in this in vivo setting.

Detailed Description

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Conditions

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Drug Effect

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pediatric patients supported on ECMO

piperacillin-tazobactam

Intervention Type DRUG

Administered for infection treatment or prophylaxis per hospital protocol

Cefazolin

Intervention Type DRUG

Administered for infection treatment or prophylaxis per hospital protocol

Interventions

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piperacillin-tazobactam

Administered for infection treatment or prophylaxis per hospital protocol

Intervention Type DRUG

Cefazolin

Administered for infection treatment or prophylaxis per hospital protocol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* supported on ECMO
* receive piperacillin-tazobactam or cefazolin as part of routine care or infection management

Exclusion Criteria

* \>= 18 years
* No Consent provided
Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Katie Moynihan

Cardiac Intensivist

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Boston Children's Hospital

Boston, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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IRB-P00030970

Identifier Type: -

Identifier Source: org_study_id

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