A Study to Identify Participants With Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations

NCT ID: NCT03955913

Last Updated: 2023-02-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3679 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-01

Study Completion Date

2022-09-19

Brief Summary

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The purpose of this non-interventional study is to identify participants with urothelial cancer (UC) and selected fibroblast growth factor receptor (FGFR) aberrations through molecular testing of their archival tumor tissue.

Detailed Description

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Conditions

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Urothelial Cancer Receptors, Fibroblast Growth Factor

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Participants with Urothelial Cancer,selected FGFR aberrations

Participants with urothelial cancer (UC) will be evaluated for the prevalence of positive results of selected fibroblast growth factor receptor (FGFR) aberrations and will be assessed for eligibility status for erdafitinib studies. The primary data source for this study will be the medical records of each participant.

Archival Tumor Tissue Sample

Intervention Type OTHER

Percentage of participants with UC and selected FGFR aberrations will be assessed through molecular testing of their archival tumor tissue.

Interventions

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Archival Tumor Tissue Sample

Percentage of participants with UC and selected FGFR aberrations will be assessed through molecular testing of their archival tumor tissue.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Transitional cell carcinoma of the urothelium. Urothelial cell carcinoma (UCC) variants are allowed, that is, UCC with squamous and/or glandular differentiation, micropapillary, nested, plasmacytoid, neuroendocrine, and sarcomatoid
* Diagnosis of one of the following: a) Metastatic or surgically unresectable urothelial cancer (UC) (Stage IV) or, b) localized surgically-resectable or resected UC with a T classification of T2 or above or non-muscle-invasive urothelial carcinoma of the bladder (Ta, T1 and carcinoma in situ \[CIS\])
* Available archival tissue sample for fibroblast growth factor receptor (FGFR) aberration analysis

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Janssen Research & Development, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Janssen Research & Development, LLC Clinical Trial

Role: STUDY_DIRECTOR

Janssen Research & Development, LLC

Locations

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Arizona Oncology Associates, PC - HOPE

Tucson, Arizona, United States

Site Status

Rocky Mountain Cancer Centers

Denver, Colorado, United States

Site Status

Medical Oncology Hematology Consultants, PA

Newark, Delaware, United States

Site Status

Affiliated Oncologists, LLC

Chicago Ridge, Illinois, United States

Site Status

Maryland Oncology Hematology, PA

Brandywine, Maryland, United States

Site Status

Minnesota Oncology Hematology, P.A.

Minneapolis, Minnesota, United States

Site Status

New York Oncology Hematology

Albany, New York, United States

Site Status

Broome Oncology

Johnson City, New York, United States

Site Status

Oncology Hematology Care

Cincinnati, Ohio, United States

Site Status

Willamette Valley Cancer Institute and Research Center

Eugene, Oregon, United States

Site Status

Northwest Cancer Specialists PC

Tualatin, Oregon, United States

Site Status

Consultants in Medical Oncology and Hematology, P.C. - Abington

Horsham, Pennsylvania, United States

Site Status

Texas Oncology-Baylor Charles A. Sammons Cancer Center

Dallas, Texas, United States

Site Status

Texas Oncology-Denton South

Denton, Texas, United States

Site Status

Texas Oncology, P.A. - Flower Mound

Flower Mound, Texas, United States

Site Status

Texas Oncology-Fort Worth Cancer Center

Fort Worth, Texas, United States

Site Status

Texas Oncology-Memorial City

Houston, Texas, United States

Site Status

Texas Oncology-Midland Allison Cancer Center

Midland, Texas, United States

Site Status

University of Texas at San Antonio

San Antonio, Texas, United States

Site Status

Texas Oncology-Sherman

Sherman, Texas, United States

Site Status

Texas Oncology-Tyler

Tyler, Texas, United States

Site Status

Texas Oncology -Waco

Waco, Texas, United States

Site Status

Virginia Oncology Associates

Norfolk, Virginia, United States

Site Status

CIPREC

Buenos Aires, , Argentina

Site Status

Investigaciones Clinico Moleculares (ICM)

CABA, , Argentina

Site Status

FUCDIM - Centro Urológico Modelo

Córdoba, , Argentina

Site Status

Sanatorio Allende Cerro

Córdoba, , Argentina

Site Status

Instituto Médico de Río Cuarto

Córdoba, , Argentina

Site Status

Hospital Privado de Cordoba

Córdoba, , Argentina

Site Status

Sanatorio Mayo SA

Santa Fe, , Argentina

Site Status

Jolimont

Haine-Saint-Paul, La Louviere, , Belgium

Site Status

Az Groeninge

Kortrijk, , Belgium

Site Status

CHU de Liège - Domaine Universitaire du Sart Tilman

Liège, , Belgium

Site Status

ZNA Jan Palfijn

Merksem, , Belgium

Site Status

CHU UCL Namur - Site Sainte Elisabeth

Namur, , Belgium

Site Status

Clinique Saint Pierre

Ottignies, , Belgium

Site Status

CHPLT Verviers

Verviers, , Belgium

Site Status

NAIC - Nair Antunes Instituto do Câncer

Bauru, , Brazil

Site Status

Santa Casa de Misericordia de Belo Horizonte

Belo Horizonte, , Brazil

Site Status

Nucleo de Ensino e Pesquisa do Instituto Mario Penna

Belo Horizonte, , Brazil

Site Status

Clinica de Oncologia Reichow

Blumenau, , Brazil

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Universidade Estadual De Campinas

Campinas, , Brazil

Site Status

Instituto Do Cancer Do Hospital Pompeia

Caxias do Sul, , Brazil

Site Status

Instituto de Oncologia do Paraná

Curitiba, , Brazil

Site Status

Ynova Pesquisa Clinica

Florianópolis, , Brazil

Site Status

Associacao de Combate ao Cancer em Goias - Hospital de Cancer Araujo Jorge

Goiânia, , Brazil

Site Status

SCMI Santa Casa de Misericórdia de Itabuna

Itabuna, , Brazil

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Fundacao Doutor Amaral Carvalho

Jaú, , Brazil

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Cepeville - Centro de Hematologia e Oncologia

Joinville, , Brazil

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Hospital do Cancer de Londrina

Londrina, , Brazil

Site Status

Instituto Sensumed de Ensino e Pesquisa Ruy França - ISENP

Manaus, , Brazil

Site Status

Irmandade Santa Casa de Misericordia de Porto Alegre

Porto Alegre, , Brazil

Site Status

Hospital Ernesto Dornelles

Porto Alegre, , Brazil

Site Status

IRPCC - Instituto Ribeiraopretano de Combate ao Cancer

Ribeirão Preto, , Brazil

Site Status

Núcleo de Oncologia da Bahia

Salvador, , Brazil

Site Status

Ensino e Terapia de Inovacao Clinica AMO - Etica

Salvador, , Brazil

Site Status

Centro de Pesquisa em Oncologia Onco SG

Santa Cruz do Sul, , Brazil

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Hospital Paulistano

São Paulo, , Brazil

Site Status

Instituto de Oncologia de Sorocaba/Onco Clinicas Especializadas

Sorocaba, , Brazil

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Instituto do Cancer De Tres Lagoas

Três Lagoas, , Brazil

Site Status

Associacao Feminina de Educacao e Combate ao Cancer - Hospital Santa Rita de Cassia

Vitória, , Brazil

Site Status

CEDOES - Centro de Pesquisa Clinica e Diagnostico do Espirito Santo Ltda.

Vitória, , Brazil

Site Status

Polyclinique du Parc Rambot

Aix-en-Provence, , France

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CHU Amiens Picardie

Amiens, , France

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Hôpital Privé d'Anthony

Antony, , France

Site Status

Institut Sainte Catherine

Avignon, , France

Site Status

Centre Hospitalier de Boulogne-sur-Mer

Boulogne-sur-Mer Cédex, , France

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Hôpital de Fleyriat

Bourg-en-Bresse, , France

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Centre Hospitalier Dr Jean-Eric TECHER

Calais, , France

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CH Chambéry

Chambéry, , France

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Centre Hospitalier Alpes Léman

Contamine-sur-Arve, , France

Site Status

Institut Andree DUTREIX

Dunkirk, , France

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Centre Hospitalier Annecy Genevois

Epagny Metz-Tessy, , France

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Centre Hospitalier Eure-Seine - Hopitaux d'Evreux - Vernon

Évreux, , France

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Clinique de la Sauvegarde

Lyon, , France

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Hôpital Privé Clairval

Marseilli, , France

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Ch De St Quentin

Saint-Quentin, , France

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Hôpital Privé Drome Ardèche

Valence, , France

Site Status

Ch Bretagne Atlantique De Vannes

Vannes, , France

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Markus Krankenhaus Frankfurt

Frankfurt, , Germany

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Prostata zentrum Nordwest

Gronau, , Germany

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Marien hospital Herne

Herne, , Germany

Site Status

MVZ Urologie 24 gGmbH

Nuremberg, , Germany

Site Status

ELBLANDKLINIKUM Riesa

Riesa, , Germany

Site Status

Hegau Klinikum Singen

Singen, , Germany

Site Status

Urologischen Praxisgemeinschaft

Wolfsburg, , Germany

Site Status

Haemek Medical Center - Afula

Afula, , Israel

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Carmel Medical Center

Haifa, , Israel

Site Status

Azienda Ulss 6 Euganea- Ospedale Di Camposampiero

Camposampiero, , Italy

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Ospedale Di Carrara

Carrara, , Italy

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Fondazione Istituto G. Giglio

Cefalù, , Italy

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Hospital SS Annunziata - University G.D'Annunzio

Chieti, , Italy

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Ospedale Città Di Castello

Città di Castello, , Italy

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Az. USL 12 di Viareggio Ospedale Versilia

Lido di Camaiore, , Italy

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Ospedale San Luca

Lucca, , Italy

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Azienda Ospedaliera Carlo Poma

Mantova, , Italy

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Azienda Ospedaliera Ospedale San Carlo Borromeo

Milan, , Italy

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Ospedale Civile di Mirano

Mirano (VE), , Italy

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Azienda Ospedaliera 'A. Cardarelli'

Napoli, , Italy

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Ospedale Buccheri La Ferla Fatebenefratelli

Palermo, , Italy

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A.O.R Villa Sofia Cervello

Palermo, , Italy

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Casa di Cura La Maddalena

Palermo, , Italy

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Policlinico San Pietro

Ponte San Pietro, , Italy

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Nuovo Ospedale Di Prato - S. Stefano

Prato, , Italy

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Asst Rhodense - Ospedale Di Rho

Rho, , Italy

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Polo Ospedaliero Unico Integrato- Presidio S.Camillo De Lellis Di Rieti

Rieti, , Italy

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Istituto Nazionale Tumori Regina Elena

Roma, , Italy

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Ospedale Generale Provinciale - Saronno

Saronno, , Italy

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Ospedale Bolognini

Seriate, , Italy

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Ospedale Treviglio-Caravaggio

Treviglio, , Italy

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SC Oncologia ASL CN2

Verduno (CN), , Italy

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Azienda Ulss 8 Berica- Ospedale Di Vicenza

Vicenza, , Italy

Site Status

Azienda Ospedaliera "Ospedale Civile" di Vimercate - Ospedal

Vimercate, , Italy

Site Status

The Jikei University Kashiwa Hospital

Chiba, , Japan

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Juntendo University Hospital Urayasu

Chiba, , Japan

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National Hospital Organization Mito Medical Center

Higashiibaraki-gun, , Japan

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Teine Keijinkai Hospital

Hokkaido, , Japan

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Hitachinaka General Hospital

Ibaraki, , Japan

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Ikeda City Hospital

Ikeda, , Japan

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Japanese Red Cross Ise Hospital

Ise, , Japan

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Isesaki Municipal Hospital

Isesaki, , Japan

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Kaizuka City Hospital

Kaizuka, , Japan

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Kanagawa Cancer Center

Kanagawa, , Japan

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Mitoyo General Hospital

Kan’onjichō, , Japan

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National Hospital Organization Osaka Minami Medical Center

Kawachi-Nagano, , Japan

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Kiryu Kosei General Hospital

Kiryū, , Japan

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Kimitsu Chuo Hospital

Kisarazu-shi, , Japan

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Saitama Cancer center

Kitaadachi-gun, , Japan

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Kitasato University Medical Center

Kitamoto, , Japan

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Dokkyo Medical University Saitama Medical Center

Koshigaya, , Japan

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Kitasato University Kitasato Institute Hospital

Minatoku, , Japan

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Japanese Red Cross Mito Hospital

Mito, , Japan

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Japanese Red Cross Narita Hospital

Narita, , Japan

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Juntendo University Nerima Hospital

Nerima-Ku, , Japan

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Kobe City Nishi-Kobe Medical Center

Nishiku, , Japan

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National Hospital Organization Osaka National Hospital

Osaka, , Japan

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Otemae Hospital

Osaka, , Japan

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Osaka Police Hospital

Osaka, , Japan

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Osaka General Medical Center

Osaka, , Japan

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JOHAS Osaka Rosai Hospital

Osaka, , Japan

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SUBARU Health Insurance Society Ota Memorial Hospital

Ōta-ku, , Japan

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National Hospital Organization Sagamihara National Hospital

Sagamihara, , Japan

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Sakai City Medical Center

Sakai, , Japan

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Jinyukai Hospital

Sapporo, , Japan

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Mitsui Memorial Hospital

Tokyo, , Japan

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Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

Tokyo, , Japan

Site Status

Tsuchiura Kyodo General Hospital

Tsuchiura, , Japan

Site Status

Tsukuba Medical Center Hospital

Tsukuba, , Japan

Site Status

State Budgetary Healthcare Institution Inter-regional Multi-specialty Hospital

Anzorey, , Russia

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LLC Evimed

Chelyabinsk, , Russia

Site Status

FSBI A.V. Vishnevsky National Medical Research Center of Surgery of the MoH RF

Moscow, , Russia

Site Status

LLC 1 named after Berezin Sergey

Saint Petersburg, , Russia

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Oncology Medical Clinics AV Medical group

Saint Petersburg, , Russia

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Komi Republican Oncology Dispensary

Syktivkar, , Russia

Site Status

Tomsk National Research Medical Center of the Russian Academy of Sciences

Tomsk, , Russia

Site Status

Yaroslavl Regional Clinical Oncology Hospital

Yaroslavl, , Russia

Site Status

SHI Sverdlovsk Regional Clinical Hospital #1

Yekaterinburg, , Russia

Site Status

Hosp. Univ. Fundacion Alcorcon

Alcorcón, , Spain

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Hosp. Gral. de Granollers

Barcelona, , Spain

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Hosp. Puerta Del Mar

Cadiz, , Spain

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Hosp. Univ. Donostia

Donostia / San Sebastian, , Spain

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Genesiscare Jerez de La Frontera

Jerez de la Frontera, , Spain

Site Status

Hosp. Univ. de La Princesa

Madrid, , Spain

Site Status

Hosp. Univ. Del Henares

Madrid, , Spain

Site Status

Hosp. Univ. Central de Asturias

Oviedo, , Spain

Site Status

Hosp. Univ. Infanta Sofia

San Sebastián de los Reyes, , Spain

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Hosp. Quiron Sagrado Corazon

Seville, , Spain

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Hosp. de Terrassa

Terrassa, , Spain

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Hosp. Virgen de La Salud

Toledo, , Spain

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Adana Acibadem Hospital

Adana, , Turkey (Türkiye)

Site Status

Dr.Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, , Turkey (Türkiye)

Site Status

Adnan Menderes University Training and Research Hospital

Aydin, , Turkey (Türkiye)

Site Status

Canakkale Onsekiz Mart University Health Practices and Research Hospital

Çanakkale, , Turkey (Türkiye)

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Şişli Etfal Research Training Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Haydarpasa Numune Training and Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Kartal Dr. Lutfi Kirdar Egitim ve Arastirma Hastanesi

Istanbul, , Turkey (Türkiye)

Site Status

Izmir Katip Celebi University Ataturk Training and Research Hospital

Izmir, , Turkey (Türkiye)

Site Status

Izmir Medical Park Hospital

Izmir, , Turkey (Türkiye)

Site Status

Derince Egitim ve Arastirma Hastanesi

Kocaeli, , Turkey (Türkiye)

Site Status

Necmettin Erbakan University Meram Medical Faculty

Konya, , Turkey (Türkiye)

Site Status

Manisa Celal Bayar University

Manisa, , Turkey (Türkiye)

Site Status

Medical Park Samsun Hastanesi

Samsun, , Turkey (Türkiye)

Site Status

Ondokuz Mayis University

Samsun, , Turkey (Türkiye)

Site Status

Municipal Non-profit enterprise 'Bukovinian clinical oncology center'

Chernivtsi, , Ukraine

Site Status

Communal Institution 'City hospital №7 of Kamianske' of Dnepropetrov'sk Regional Council

Kamianske, , Ukraine

Site Status

Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval

Kharkiv, , Ukraine

Site Status

Khmelnitckiy regional hospital

Khmelnytsky, , Ukraine

Site Status

Communal Nonprofit Enterprise 'Regional Clinical Oncology Center of Kirovohrad Regional Council'

Kropyvnytskyi, , Ukraine

Site Status

State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center

Kyiv, , Ukraine

Site Status

Lviv Clinical Regional Hospital

Lviv, , Ukraine

Site Status

ME 'Poltava Regional Clinical Hospital n.a. M.V. Sklifosovsky of the Poltava Regional Council'

Poltava, , Ukraine

Site Status

Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal

Uzhhorod, , Ukraine

Site Status

Medical Center 'Diaservis'

Zaporizhzhia, , Ukraine

Site Status

Communal Institution 'Regional Oncology Dispensary' of Zhytomyr Region Council

Zhytomyr, , Ukraine

Site Status

Colchester Hospital University NHS

Colchester, , United Kingdom

Site Status

Royal Devon & Exeter Hospital

Exeter, , United Kingdom

Site Status

The Clatterbridge Cancer Centre

Metropolitan Borough of Wirral, , United Kingdom

Site Status

Queen Alexandra Hospital

Portsmouth, , United Kingdom

Site Status

Royal Preston Hospital

Preston, , United Kingdom

Site Status

Countries

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United States Argentina Belgium Brazil France Germany Israel Italy Japan Russia Spain Turkey (Türkiye) Ukraine United Kingdom

Other Identifiers

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42756493BLC0002

Identifier Type: OTHER

Identifier Source: secondary_id

CR108627

Identifier Type: -

Identifier Source: org_study_id

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