Study of Genes and the Environment in Patients With Prostate Cancer Residing in the East Anglia, Trent, or West Midlands Regions of the United Kingdom
NCT ID: NCT00758173
Last Updated: 2013-08-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
2000 participants
OBSERVATIONAL
2008-02-29
Brief Summary
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PURPOSE: This study is looking at genetic susceptibility and the interactions between genes and the environment in patients with prostate cancer.
Detailed Description
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* To obtain epidemiological information and biological material on a population-based series of prostate cancer cases.
* To identify novel cancer susceptibility genes by comparison of genotype frequencies in cases with the corresponding frequencies in large control series.
* To estimate the age and sex-specific risks associated with variants in predisposition genes.
* To evaluate interactions between polymorphisms in predisposition genes and potential lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire, including information on education, occupation, smoking habits, alcohol consumption, height, weight, family history of cancer, and past medical history.
Blood samples are collected from patients. DNA is extracted from these blood samples and from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL as well as from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the prostate cancer patients recruited for this study, patients with breast, ovarian, endometrial, colorectal, bladder, kidney, pancreatic, brain and esophageal cancer, malignant melanoma, and lymphoma cancer are recruited in the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-CANCER.
Conditions
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Keywords
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Interventions
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polymorphism analysis
laboratory biomarker analysis
questionnaire administration
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of prostate cancer within the past 5 years
* Identified through the cancer registry serving any of the following geographic regions of the United Kingdom:
* East Anglia
* Trent
* West Midlands
PATIENT CHARACTERISTICS:
* Identified by the patient's general practitioner as fit to contact for this study
* No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
* Not specified
18 Years
74 Years
MALE
No
Sponsors
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Cancer Research UK
OTHER
Principal Investigators
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Paul Pharoah, MD
Role: STUDY_CHAIR
Cancer Research UK
Locations
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University of Cambridge Cancer Research UK
Cambridge, England, United Kingdom
Countries
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Facility Contacts
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Contact Person
Role: primary
Other Identifiers
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MREC-SEARCH-PROSTATE
Identifier Type: -
Identifier Source: secondary_id
CDR0000589199
Identifier Type: -
Identifier Source: org_study_id