Blood Samples From Healthy Volunteers for Genetic Studies in the East Anglia Region of the United Kingdom
NCT ID: NCT00757991
Last Updated: 2013-08-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
4000 participants
OBSERVATIONAL
2008-02-29
Brief Summary
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PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in healthy volunteers.
Detailed Description
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* To obtain blood samples and simple epidemiological information on a population-based series of adult individuals without cancer.
* To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer by comparing the frequency of alterations in these genes with the corresponding frequency in a comparable series of cancer patients.
* To examine the interactions between genetic and non-genetic risk factors.
OUTLINE: This is a multicenter study.
Participants complete a simple epidemiological questionnaire.
Participants undergo blood sample collection. DNA is extracted from these samples for polymorphism analysis of low penetrance cancer susceptibility genes in the following related clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL.
PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for this study.
Conditions
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Keywords
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Interventions
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polymorphism analysis
laboratory biomarker analysis
questionnaire administration
Eligibility Criteria
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Inclusion Criteria
* Cancer-free participants randomly selected from the age-sex registry of a general practice in the East Anglia region of the United Kingdom
* Two general practices from each district within East Anglia participate (up to 10 total participating practices)
PATIENT CHARACTERISTICS:
* Identified by the participant's general practitioner as fit to contact for this study
* No prior diagnosis of cancer
* No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
* Not specified
35 Years
69 Years
ALL
Yes
Sponsors
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Cancer Research UK
OTHER
Principal Investigators
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Paul Pharoah, MD
Role: STUDY_CHAIR
Cancer Research UK
Locations
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University of Cambridge Cancer Research UK
Cambridge, England, United Kingdom
Countries
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Facility Contacts
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Contact Person
Role: primary
Other Identifiers
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MREC-SEARCH-CONTROL
Identifier Type: -
Identifier Source: secondary_id
MREC-07/MRE05/17
Identifier Type: -
Identifier Source: secondary_id
CDR0000598880
Identifier Type: -
Identifier Source: org_study_id