Combination With Treg Levels and CMR to Assess the Severity and Prognosis of Reperfusion Injury After PPCI in STEMI Patients

NCT ID: NCT03939338

Last Updated: 2019-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-07-01

Study Completion Date

2021-08-31

Brief Summary

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This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in STEMI patients receiving primary percutaneous coronary intervention (PPCI).

Detailed Description

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Conditions

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STEMI - ST Elevation Myocardial Infarction Reperfusion Injury, Myocardial

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Participates

Treg levels and CMR results

Intervention Type OTHER

This is an observational study. Exposure: Different Treg levels and CMR results.

Interventions

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Treg levels and CMR results

This is an observational study. Exposure: Different Treg levels and CMR results.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Confirmed STEMI diagnosis
* Undergoing primary percutaneous coronary intervention (presenting \<12 hours after symptom onset)
* Patients were able to complete cardiac magnetic resonance imaging (CMR) and speckle tracking imaging echocardiogram (STE) examinations
* Patients agreed and provided informed consent

Exclusion Criteria

* Previous myocardial infarction or revascularization (PCI or CABG)
* Congestive heart failure with LVEF\<40%
* Atrial fibrillation
* Renal insufficiency (GFR \< 30 ml/min/1.73m\^2)
* Acute infectious diseases within nearly 3 months
* Rheumatic immune system diseases
* Malignant tumors
* Claustrophobia
* Contraindicated to CMR
* Patients do not agree to be included in the study
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Friendship Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hongwei Li, MD

Prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Hongwei Li, M.D.

Role: CONTACT

0086 10 63139780

Facility Contacts

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Bing Hua, M.D.

Role: primary

0086 10 63139795

References

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Zhang Y, Gao H, Liu L, Li S, Hua B, Lan D, He Y, Li J, Chen H, Li W, Li H. Regulatory T Cell as Predictor of Intramyocardial Hemorrhage in STEMI Patients after Primary PCI. Rev Cardiovasc Med. 2023 Jul 14;24(7):205. doi: 10.31083/j.rcm2407205. eCollection 2023 Jul.

Reference Type DERIVED
PMID: 39077002 (View on PubMed)

Other Identifiers

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BFH-Treg and CMR

Identifier Type: -

Identifier Source: org_study_id

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