Analysis of Circulating Epithelial Tumor Cells in Peripheral Blood in Patients With Primary Non-metastatic Breast Cancer Under Adjuvant Radiotherapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

161 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-09-01

Study Completion Date

2018-09-01

Brief Summary

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The aim of this study was to investigate the systemic effect of radiotherapy on patients with primary non-metastatic breast cancer using CETC and to analyze possible changes in CETC quantity under adjuvant radiotherapy.

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Detailed Description

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In cooperation with the Women's Hospital of the Friedrich Schiller University in Jena, a total of 161 patients with clinically proven, primarily non-metastatic breast cancer were sampled and examined before and after radiotherapy over a period from 09/2002 to 09/2012. The MAINTRAC method was used to quantitatively determine the amount of CETC in the blood and to observe its peritherapeutic course.

Conditions

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Breast Cancer Female

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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primary non-metastatic breast cancer

radiation

Intervention Type RADIATION

Interventions

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radiation

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* histologically confirmed invasive breast carcinoma
* age \>= 18 years
* exclusive treatment at the Jena University Hospital
* complete curative-intended adjuvant or definite radiotherapy
* at least 2 blood collections (before the start of therapy, after the end of the RT)

Exclusion Criteria

* presence of metastases
* recurrence
* DCIS, inflammatory breast cancer
* second malignancy \<10 years before diagnosis of breast cancer
* radiotherapeutic pretreatment

Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No