Interest of Functional Neuroimaging in Assessing Decision-making Capacity of Older People With Neurocognitive Disorders
NCT ID: NCT03931148
Last Updated: 2021-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
74 participants
INTERVENTIONAL
2020-01-05
2023-04-30
Brief Summary
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Detailed Description
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Nevertheless, there is no test that specifically explores this issue and, therefore, people's decision-making abilities may not be properly estimated and may prevent some patients from making decisions when they would be able to do so.
Thus, although the issue of decision-making has generally been explored from a neuropsychological perspective in many studies, there is no specific test or score for decision-making capacity, as it is a complex process. The question of decision-making capacity in complex situations is therefore addressed by a multiple analysis of many parameters, including different neuropsychological data, which are then synthesized by the clinician in a standardized geriatric assessment to get an idea, among other things, of the overall ability to make decisions.
Given the difficulty of this and the ethical and societal issue, the research question focuses on the contribution of neuroimaging technologies to the assessment of decision-making capacity.
In fact, several studies have explored the issue as part of the functional neuroimaging study. The investigators note, in particular:
* Decision-making studies were conducted using the EEG-High Resolution (EEG-HR) technique. It is a technique for electromagnetic analysis of brain functions with excellent temporal resolution and quite good spatial resolution. This allows, during functional decision tests, a detailed analysis of the temporality of the activation of the frontal and prefrontal areas.
* Functional MRI (fMRI) is a neurological imaging technique whose main strength lies in its spatial acuity. Thus, the performance of functional decisional tests under functional MRI allows a detailed analysis of the recruitment of the different zones between the dorsolateral prefrontal cortex and the median ventromedian cortex.
These 2 neuroimaging techniques allowed a neuro-functional analysis of decision making, based on the realization of more specific tests, modelling decision making. Among these models, the Iowa Game Task and the Balloon Assessement Risk Task are frequently used.
Nevertheless, all these tests and explorations were conducted independently, and no studies have investigated the contribution of a neurofunctional approach to patient decision-making through complementary explorations in functional MRI and /or in EEG-HR as diagnostic tools as part of an overall gerontological evaluation of decision making ability.
The question that arises is therefore that of the development of diagnostic tools.
Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Intervention
After first consultation for diagnosis of neurodegenerative disorder :
* Geriatric Assessment with specific neuropsychologic tests of decision making
* fRMI
* EEG High Resolution
* Qualitative interview
Geriatric Assesment with neuropsychological test more specific on decision making
The following tests will be made : MoCA, FAB, TMT, Stroop-Victoria, JAT
Functional RMI
With specific test of decision making (IGT) specially adapted to the population
High Resolution EEG
With specific test of decision making (BART) specially adapted to the population
Qualitative interview
Qualitative semi-directed interviews with participants, their caregivers and their geriatrician to analyse everyday life decision making ability.
Interventions
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Geriatric Assesment with neuropsychological test more specific on decision making
The following tests will be made : MoCA, FAB, TMT, Stroop-Victoria, JAT
Functional RMI
With specific test of decision making (IGT) specially adapted to the population
High Resolution EEG
With specific test of decision making (BART) specially adapted to the population
Qualitative interview
Qualitative semi-directed interviews with participants, their caregivers and their geriatrician to analyse everyday life decision making ability.
Eligibility Criteria
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Inclusion Criteria
* Recent diagnosis of neurocognitive disorder
* Agreed with the study
Exclusion Criteria
* Major depressive symptoms
* MRI contraindication
70 Years
ALL
No
Sponsors
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Université de Montréal
OTHER
Centre Hospitalier Universitaire de Besancon
OTHER
Responsible Party
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Thomas TANNOU
University Hospital Practitioner
Principal Investigators
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Regis AUBRY, PhD
Role: STUDY_CHAIR
Centre Hospitalier Universitaire de Besancon
Locations
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CRIUGM
Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Besancon
Besançon, Bourgogne-Franche-Comté, France
Countries
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Central Contacts
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Facility Contacts
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Thomas TANNOU, MD
Role: primary
References
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Tannou T, Godard-Marceau A, Joubert S, Daneault S, Kergoat MJ, Magnin E, Comte A, Gabriel D, Vidal C, Pazart L, Aubry R. Added value of functional neuroimaging to assess decision-making capacity of older adults with neurocognitive disorders: protocol for a prospective, monocentric, single-arm study (IMAGISION). BMJ Open. 2021 Sep 29;11(9):e053549. doi: 10.1136/bmjopen-2021-053549.
Other Identifiers
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API3A2018
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
Don Du Souffle 2018
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
Prix H Mutuelle Alzheimer 2019
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
API/2018/100
Identifier Type: -
Identifier Source: org_study_id
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