Bio Metrology of Nonfibrous Mineral Particles in Bronchoalveolar Lavage Fluids

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

105 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-05

Study Completion Date

2023-06-02

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main purpose of this study is to update the pulmonary retention values of non-fibrous mineral particles in the general population.

This study will provide reference values for the interpretation and diagnosis of the cause of certain respiratory diseases potentially related to mineral particles.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Measurement of Soluble Factors and Particulate Matter in Induced Sputum and EBC in Inflammatory Diseases of the Lung

NCT00511290

Asthma Chronic Obstructive Pulmonary Disease Interstitial Lung Diseases +1 more

COMPLETED

Study of the Impact of Exposure to Outdoor and Indoor Pollutants in Patients With Asthma

NCT05525169

Asthma

UNKNOWN

Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease

NCT01949181

Lung Cancer Chronic Obstructive Pulmonary Disease Emphysema +1 more

COMPLETED NA

Exploratory Study of Potential Pulmonary Aspiration Markers From Bronchoalveolar Lavage Fluid

NCT00915941

Bronchoscopy

COMPLETED

Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD

NCT05437198

Chronic Obstructive Pulmonary Disease

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Some non-fibrous mineral particles are responsible for respiratory or systemic diseases, most often of occupational origin. Their use concerns multiple professional sectors.

The bio metrology of these particles, namely their quantification in a biological medium requires reference values. These are essential for clinicians to interpret pulmonary retention in patients who may have been exposed professionally or environmentally to non-fibrous mineral particles.

A comparative study conducted in 2015 by lafp showed an increase in the particulate load of nonfibrous mineral particles, including titanium, in lung parenchyma samples over time.

Bronchoalveolar lavage fluid is typically considered to be representative of the lung for the analysis of nonfibrous mineral particles. The thresholds currently used for the bio metrology of nonfibrous mineral particles in bronchoalveolar lavage fluid samples are based on reference values established more than 20 years ago. It is therefore appropriate to update these reference values by establishing a new control population from the analysis of bronchoalveolar lavage fluid from subjects not exposed to the non-fibrous mineral particles in a professional or environmental manner.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Occupational Exposure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Subjects not exposed to Non-fibrous Mineral Particle in a professional and / or environmental way.
* Smokers and non-smokers (or weaners who have been weaned for at least 5 years).
* Acceptance to participate in the protocol.
* Affiliated to a social security scheme.

Exclusion Criteria

* Suspicion of fibrosing pulmonary pathologies.
* Suspicion of pulmonary sarcoidosis ≥ stage 2, pneumoconiosis.
* Subjects with cystic fibrosis.
* Subjects chronic obstructive pulmonary disease (COPD) stage ≥ 3.
* Presence of serious comorbidities that are life-threatening in the short term.
* Refusal to participate in the study.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes