Impact of CYP3A4*1G Polymorphism on Non-analgesic Effects of Fentanyl in Chinese Han Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-10

Study Completion Date

2021-05-20

Brief Summary

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Purpose: This study aimed to investigate the impact of CYP3A4\*1G genetic polymorphism on non-analgesic effects of fentanyl in Chinese Han patients. Methods: 200 patients receiving elective surgery under general anesthesia were recruited into this study. Venous blood was withdrawn for genotyping of CYP3A4\*1G before operation. Fentanyl 2 µg/kg was administered preoperatively. Bispectral Index (BIS), Respiratory rate(RR), etc at Tb (entering room), T0 (drug administration), T1 (2min), T2 (4min), T3(6min), T4(8min), T5(10min), T6(20min) were recorded.

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Detailed Description

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Conditions

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Fentanyl

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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GG

wild-type homozygote (CYP3A4\*1/\*1, GG)

No interventions assigned to this group

GA

mutant heterozygote (CYP3A4\*1/\*1G, GA),

No interventions assigned to this group

AA

mutant homozygote (CYP3A4\*1G/\*1G, AA)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* American Society of Anesthesiologists GradeⅠ-II,Patients undergo elective surgery for benign Reproductive diseases (including laparoscopic ovarian cyst removal, laparoscopic tubal ligation, laparoscopic tubal drainage, laparoscopic salpingoplasty, etc.) or breast disease.
* Aged 18-45 years
* Body Mass Index 18-25kg/m2,body weight 40-65 kilograms
* Agreed to participate the research

Exclusion Criteria

* Difficult airway
* upper respiratory tract infection within 2 weeks
* history of allergy or long-term use of propofol and opioids
* self-rating anxiety scale before operation indicates anxiety
* pregnancy or lactation.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No