Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis
NCT ID: NCT03854565
Last Updated: 2019-02-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
336 participants
OBSERVATIONAL
2019-05-01
2019-12-31
Brief Summary
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Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Mild ARDS
patients have mild ARDS according to Berlin definition
Glycocalyx measurement，respiratory mechanics measurement
ELASA measure glycocalyx, measure plateau pressure, driving pressure
Moderate ARDS
patients have moderate ARDS according to Berlin definition
Glycocalyx measurement，respiratory mechanics measurement
ELASA measure glycocalyx, measure plateau pressure, driving pressure
Severe ARDS
patients have severe ARDS according to Berlin definition
Glycocalyx measurement，respiratory mechanics measurement
ELASA measure glycocalyx, measure plateau pressure, driving pressure
Interventions
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Glycocalyx measurement，respiratory mechanics measurement
ELASA measure glycocalyx, measure plateau pressure, driving pressure
Eligibility Criteria
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Inclusion Criteria
2. Meet ARDS Berlin definition
3. With mechanical ventilation
Exclusion Criteria
2. have use heparin or low molecular heparin or chondroitin sulfuric acid
18 Years
80 Years
ALL
No
Sponsors
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Southeast University, China
OTHER
Responsible Party
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Chun Pan
Principal Investigator
Principal Investigators
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Chun C Pan, Dr
Role: PRINCIPAL_INVESTIGATOR
Zhongda hospital, Southeast University, Jiangsu, China
Locations
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Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Decorin-ARDS fibrosis study
Identifier Type: -
Identifier Source: org_study_id
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