Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015)

NCT ID: NCT03830333

Last Updated: 2023-01-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 268 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-03-20
• Study Completion Date: 2020-10-14

Brief Summary

This study aims to evaluate the efficacy of ceftolozane/tazobactam (MK-7625A) plus metronidazole versus meropenem in adults diagnosed with complicated intra-abdominal infection (cIAI). The primary hypothesis is ceftolozane/tazobactam plus metronidazole is non-inferior to meropenem, as measured by the clinical response rate at the Test-of Cure (TOC) visit in the Clinically Evaluable (CE) population.

Conditions

Complicated Intra-abdominal Infections

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Ceftolozane/Tazobactam + Metronidazole

Participants receive ceftolozane/tazobactam 1500 mg (ceftolozane 1000 mg + tazobactam 500 mg) plus metronidazole 500 mg administered as an intravenous (IV) infusion every 8 hours for 4 to 14 days (per protocol, ceftolozane/tazobactam may be adjusted to 500 mg/250 mg if creatinine clearance \[CrCL\] is 30 to ≤50 mL/min)

Group Type: EXPERIMENTAL

Ceftolozane/Tazobactam

Intervention Type: DRUG

Ceftolozane 1000 mg / tazobactam 500 mg by IV infusion every 8 hours for 4 to 14 days. Participants with CrCL of 30 to ≤ 50 mL/min will receive ceftolozane 500 mg / tazobactam 250 mg.

Metronidazole

Intervention Type: DRUG

Metronidazole 500 mg by IV infusion every 8 hours for 4 to 14 days.

Meropenem + Placebo

Participants receive meropenem 1000 mg plus saline administered as an IV infusion every 8 hours for 4 to 14 days (per protocol, meropenem may be adjusted to every 12 hours if CrCL was 30 to ≤50 mL/min).

Group Type: ACTIVE_COMPARATOR

Meropenem

Intervention Type: DRUG

Meropenem 1000 mg by IV infusion every 8 hours for 4 to 14 days. Participants with CrCL of 30 to ≤ 50 mL/min will receive IV infusion every 12 hours.

Placebo

Intervention Type: DRUG

Saline by IV infusion every 8 hours for 4 to 14 days.

Interventions

Ceftolozane/Tazobactam

Ceftolozane 1000 mg / tazobactam 500 mg by IV infusion every 8 hours for 4 to 14 days. Participants with CrCL of 30 to ≤ 50 mL/min will receive ceftolozane 500 mg / tazobactam 250 mg.

Intervention Type: DRUG

Metronidazole

Metronidazole 500 mg by IV infusion every 8 hours for 4 to 14 days.

Intervention Type: DRUG

Meropenem

Meropenem 1000 mg by IV infusion every 8 hours for 4 to 14 days. Participants with CrCL of 30 to ≤ 50 mL/min will receive IV infusion every 12 hours.

Intervention Type: DRUG

Placebo

Saline by IV infusion every 8 hours for 4 to 14 days.

Intervention Type: DRUG

Other Intervention Names

MK-7625A

Eligibility Criteria

Inclusion Criteria

• Must have one of the following diagnoses in which there is evidence of bacterial intraperitoneal infection: Cholecystitis (including gangrenous cholecystitis) with rupture, perforation, or progression of the infection beyond the gallbladder wall; Acute gastric or small intestine including duodenal perforation, only if operated on > 24 hours after perforation occurs; Traumatic perforation of the intestine (including colon), only if operated on > 12 hours after perforation occurs; Appendiceal perforation or peri-appendiceal abscess; Diverticular disease with perforation or abscess; Peritonitis due to other perforated viscus or following a prior operative procedure; Intra-abdominal abscess (including liver or spleen).
• Evidence of systemic infection
• Requires surgical intervention (e.g., laparotomy, laparoscopic surgery, or percutaneous draining of an abscess) within 24 hours of (before or after) the first dose of study drug
• If participant is to be enrolled preoperatively, the participant should have radiographic evidence of gastric or bowel perforation or intra-abdominal abscess or other radiographic evidence for cIAI
• Participants who failed prior antibacterial treatment for the current cIAI can be enrolled but must: (a) have a positive culture (from an intra-abdominal site or blood sample) and (b) require surgical intervention.
• Is a Chinese participant, defined as a person of Chinese descent. A potential participant who is of ex-China descent (e.g. Western European) descent living in China will be excluded
• Male agrees to use contraception during the treatment period, and for at least 30 days after the last dose of study medication, and refrain from donating sperm during this period
• Female is not pregnant or breastfeeding; is not a woman of childbearing potential (WOCBP); or if WOCBP agrees to use a contraceptive method that is highly effective, or be abstinent from heterosexual intercourse as their preferred and usual lifestyle during the treatment period, and for at least 30 days after the last dose of study medication; or must have a negative highly sensitive pregnancy test (serum) within 48 hours before the first dose of study intervention.

Exclusion Criteria

• Has any of the following diagnoses: simple appendicitis; abdominal wall abscess; small bowel obstruction or ischemic bowel disease without perforation; spontaneous (primary) bacterial peritonitis associated with cirrhosis and chronic ascites; or pelvic infections
• Has any of the following diseases: acute suppurative cholangitis; infected necrotizing pancreatitis; pancreatic abscess
• Has complicated intra-abdominal infection managed by staged abdominal repair (STAR), open abdomen technique (i.e. fascia not closed) including temporary closure of the abdomen, or any situation where infection source control was not likely to be achieved
• Has abscess that is confirmed on imaging test but has not been or cannot be managed by surgical intervention including drainage
• Is expected to be cured by only surgical intervention (e.g., drainage) without use of systemic antibiotic therapy
• Has the following underlying conditions or the following serious conditions: considered unlikely to survive during the study period (predicted life expectancy is < 4 weeks after randomization); organic brain or spinal cord disease; any rapidly-progressing disease or immediately life-threatening illness (including respiratory failure and septic shock); an immunocompromising condition
• Has a history of any hypersensitivity or allergic reaction to any beta-lactam, antibacterials, including cephalosporins, carbapenems, penicillins, or tazobactam, or metronidazole, or nitroimidazole derivatives; or if a skin test is required by local clinical regulations, has a positive skin test result if no prior history of allergic reaction to beta-lactam antibacterials
• A WOCBP who has a positive serum pregnancy test within 24 hours before the first dose of study intervention
• Used systemic antibiotic therapy with known coverage of pathogens that cause IAI for more than 24 hours during the previous 72 hours prior to the first dose of study drug, unless there is a documented treatment failure with such therapy
• For participants that are enrolled postoperatively, more than 1 dose of an active non-study antibacterial regimen administered postoperatively. For participants enrolled preoperatively, no postoperative non-study antibacterial therapy is allowed
• Participants who need additional non-study systemic antibacterial therapy with gram-negative activity in addition to study drug therapy; drugs with only gram-positive activity (eg, IV vancomycin, teicoplanin, linezolid and daptomycin) are allowed
• Anticipates treatment with traditional Chinese medicine or herbal medicine during study period
• Has received disulfiram, valproic acid or divalproex sodium within 14 days before the proposed first day of study drug or who are currently receiving probenecid
• Is currently participating in, or has participated in, any other clinical study involving the administration of investigational or experimental medication (not licensed by regulatory agencies) at the time of the presentation or during the previous 90 days prior to screening or is anticipated to participate in such a clinical study during the course of this study
• Has participated in a ceftolozane/tazobactam clinical study at any time in the past
• Has severe impairment of renal function (CrCL <30 mL/min) or requirement for peritoneal dialysis, hemodialysis or hemofiltration, or oliguria

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Medical Director

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Locations

Anhui Provincial Hospital ( Site 0033)

Hefei, Anhui, China

Navy General Hospital ( Site 0009)

Beijing, Beijing Municipality, China

Peking University Third Hospital ( Site 0002)

Beijing, Beijing Municipality, China

The First Affiliated Hospital of Guangzhou Medical University ( Site 0026)

Guangzhou, Guangdong, China

Hainan General Hospital ( Site 0042)

Haikou, Hainan, China

Baotou Central Hospital ( Site 0013)

Baotou, Inner Mongolia, China

The First People's Hospital of Changzhou ( Site 0054)

Changzhou, Jiangsu, China

Wuxi No.2 People's Hospital ( Site 0050)

Wuxi, Jiangsu, China

Wuxi People's Hospital ( Site 0020)

Wuxi, Jiangsu, China

Subei People's Hospital ( Site 0046)

Yangzhou, Jiangsu, China

Affiliated Hospital of Jiangsu University ( Site 0049)

Zhenjiang, Jiangsu, China

The First Affiliated Hospital of Nanchang University ( Site 0029)

Nanchang, Jiangxi, China

The Second Affiliated Hospital of Nanchang University ( Site 0053)

Nanchang, Jiangxi, China

The Second Hospital of Jilin University ( Site 0048)

Changchun, Jilin, China

Liaocheng People s hospital ( Site 0014)

Liaocheng, Shandong, China

Zhongshan Hospital of Fudan University ( Site 0001)

Shanghai, Shanghai Municipality, China

Shanghai General Hospital ( Site 0016)

Shanghai, Shanghai Municipality, China

Central Hospital of Minhang District ( Site 0052)

Shanghai, Shanghai Municipality, China

Tianjin People's Hospital ( Site 0040)

Tianjin, Tianjin Municipality, China

The First Affiliated Hospital of Xinjiang Medical University ( Site 0034)

Ürümqi, Xinjiang, China

The First Hospital of Kunming ( Site 0041)

Kunming, Yunnan, China

Taizhou Hospital of Zhejiang Province ( Site 0035)

Taizhou, Zhejiang, China

The 2nd Affiliated Hospital of Wenzhou Medical University ( Site 0051)

Wenzhou, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University ( Site 0015)

Wenzhou, Zhejiang, China

Southern Medical University Nanfang Hospital ( Site 0055)

Guangzhou, , China

Countries

China

References

Sun Y, Fan J, Chen G, Chen X, Du X, Wang Y, Wang H, Sun F, Johnson MG, Bensaci M, Huntington JA, Bruno CJ. A phase III, multicenter, double-blind, randomized clinical trial to evaluate the efficacy and safety of ceftolozane/tazobactam plus metronidazole versus meropenem in Chinese participants with complicated intra-abdominal infections. Int J Infect Dis. 2022 Oct;123:157-165. doi: 10.1016/j.ijid.2022.08.003. Epub 2022 Aug 17.

Reference Type: RESULT

PMID: 35987467 (View on PubMed)

Li Z, Kang Y, Gao H, Zhao Y, Luo D, Wang D, Zhang X, Yu J, Chu G, Cao J, Wang F, Zhao X, Jensen E, Lin G, Chen G. Pooled data from phase 3 clinical trials comparing the clinical activity of ceftolozane/tazobactam versus meropenem for the treatment of complicated intra-abdominal infections. Infect Dis (Lond). 2025 Sep 6:1-12. doi: 10.1080/23744235.2025.2544828. Online ahead of print.

Reference Type: DERIVED

PMID: 40913503 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

MK-7625A-015

Identifier Type: OTHER

Identifier Source: secondary_id

7625A-015

Identifier Type: -

Identifier Source: org_study_id