Effect of Mango on Gut Microbiota and Metabolic Health

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-15

Study Completion Date

2022-12-31

Brief Summary

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Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota. As gut microbiota may have a strong influence on cardiometabolic health, we hypothesize that mango consumption improves metabolic profile in overweight or obese individuals through beneficial changes in gut microbiota. The study of metagenomics, transcriptomics and metabolomics will be used to validate this hypothesis.

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Detailed Description

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Conditions

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Gut Microbiota Metabolic Syndrome

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Mango consumption

Group Type EXPERIMENTAL

Mango consumption

Intervention Type DIETARY_SUPPLEMENT

Daily consumption of 280 g of frozen mangos during 8 weeks. The daily dose in equivalent to a 2-cups serving.

Interventions

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Mango consumption

Daily consumption of 280 g of frozen mangos during 8 weeks. The daily dose in equivalent to a 2-cups serving.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy men and premenopausal women
* At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men
* At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L
* Caucasian origin

Exclusion Criteria

* Nicotine use
* Metabolic disorders or use of medication that may affect parameters measured in the study
* Use of dietary supplements or natural health product that may affect parameters measured in the study
* Use of antibiotics in the last 3 months
* Surgery in the last 3 months or planned during the study timeline
* Alcohol consumption \>2 drinks/day
* Weight change \>5% in the last 3 months
* Mango aversion, allergy or intolerance
* Dietary restrictions (vegetarian, gluten avoidance...)
* Berries consumption \>1 serving/day
* Pregnancy, breastfeeding or pregnancy planned within 3-6 months

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes