Dynamics of Gut Microbiome in Overweight or Obese Participants on a Modified Atkins Diet

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-31

Study Completion Date

2025-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of the study is to investigate dynamic changes in gut microbiome and its metabolites among overweight and obese participants while they are on a modified Atkins Diets.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Microbiota in Dietary Approach to Obesity

NCT04453150

Obesity

COMPLETED NA

Dietary Intervention and Intestinal Microbiota in Non-alcoholic Fatty Liver

NCT01477307

Obesity Non-alcoholic Fatty Liver Disease (NAFLD)

COMPLETED

Effect of Oral Feeding on Gastric Emptying, Gut Blood Flow, and Hormone Responses in Obese and Healthy Weight Subjects

NCT03860623

Obesity

COMPLETED

Effect of Dietary Intervention on Gut Microbiome in Hong Kong Obese Population

NCT03343561

Overweight

UNKNOWN NA

Effect of Dietary Interventions on Intestinal Flora and Metabolism

NCT04140851

Dietary Interventions

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The mechanisms of obesity are complex, involved in genes, environment, life style, and systemic and adipose tissue inflammation. Dysbiosis of gut microbiome is considered to make a difference in obesity. On the other hand, both long-term and short-term dietary interventions can induce changes in the body composition and structure and function of gut microbiome. However, it is not really clear how gut microbiome changes along with weight loss in overweight or obese.

In the present study, we aim to characterize the gut microbiome among overweight or obese participants on a modified Atkins diets. The stool and blood samples were collected by an interval of every 5% and 10% of weight loss, respectively. Data collecting mainly covers: 1) measurement of gut microbiome using metagenome and 16S rRNA sequencing techniques; 2) metabolomics of serum and gut microbiome; 3) measurement of physical activity and diets using questionnaires.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Overweight or Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. 18-55 years old;
2. BMI \> 23.9kg/m2;
3. being willing and able to receive guidelines to a modified Atkins diet;
4. signed informed consent.

Exclusion Criteria

1. patients with serious physical and mental diseases (including cardiovascular and cerebrovascular diseases, liver and kidney diseases, respiratory diseases gastrointestinal diseases, mental diseases, etc.);
2. patients with malignant tumor;
3. pregnant and lactating women;
4. those with recent relocation plans.

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes