Timing of COC Denudation and Embryo Quality

NCT ID: NCT03813745

Last Updated: 2019-12-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-25

Study Completion Date

2020-06-25

Brief Summary

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The relation between the timing of COC denudation and oocyte /embryo quality is controversial. The aim of this study is to examine whether timing of denudation of sibling oocytes has any effect on embryo quality.

Detailed Description

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Retrieved sibling cumulus-oocyte complexes (COCs) will be randomly divided into two groups, in the first group denudation will be in 30 minutes after oocyte retrieval, in second group denudation will take place after 2 hours of incubation.

Conditions

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Infertility, Female

Keywords

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embryo quality denudation IVF ICSI

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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early denudation

Cumulus-oocyte complexes will be denudated in 30 min after oocyte retrieval

early denudation

Intervention Type OTHER

COCs will be denudated in 30 min after oocyte retrieval

late denudation

Denudation will be done 2 hr after oocyte retrieval

late denudation

Intervention Type OTHER

COCs will be denudated 2 hr after oocyte retrieval

Interventions

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early denudation

COCs will be denudated in 30 min after oocyte retrieval

Intervention Type OTHER

late denudation

COCs will be denudated 2 hr after oocyte retrieval

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* COH with GnRH antagonist cycle
* 5 or more oocytes collected

Exclusion Criteria

* Fewer than 4 oocytes after retrieval
* Previous history of total fertilization failure or oocyte maturation arrest
* Male partner requiring surgical sperm retrieval (MESA or TESA).
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Acıbadem Atunizade Hospital

OTHER

Sponsor Role lead

Responsible Party

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Elif Esra Uyar

Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Acibadem Altunizade Hospitai

Istanbul, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Facility Contacts

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Esra Uyar

Role: primary

Other Identifiers

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COCdenudation

Identifier Type: -

Identifier Source: org_study_id