Impact of Relationship of Epilepsy and Attention Deficit Hyperactive Disorder
NCT ID: NCT03806946
Last Updated: 2020-04-14
Study Results
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Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2019-02-15
2020-03-01
Brief Summary
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Detailed Description
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As epilepsy is one of the commonest comorbidity with ADHD to about (40%), there are many overlap symptoms between both disorders for example:
* Behavioral features which are shared in both frontal lobe epilepsy with ADHD such as impulsivity, disinhibition, and irritability
* The electroencephalogram: there is an increase in the rate of spikes in children with ADHD with no epileptic symptoms, which supports the theory of presence similar mechanism about central nervous system dysfunction.
These reasons lead to increase obstacles for diagnosis, assessment, and treatment for both disorders.
As this comorbidity duplicates the complications (i.e. drop the school, financial cost, stress on families, negative effect on academic, vocational, social relations and self-esteem ) so there is a great need to study this comorbidity to give a proper care for these patients.
In this study, all participants will be enrolled over a period of 12 months from Assiut outpatients clinic .All participants will be assessed in the psychiatric interview by using prepared child and adolescent psychiatric sheet include (psychiatric and neurology history, physical examination and mental state examination). After that electroencephalogram(EEG) will be done to diagnoses epilepsy and identify different types of seizures.
All participants will be categorizing into 4 groups ( ADHD, epilepsy, ADHD,and epilepsy, healthy) according to EEG and the psychiatric sheet. Each group will be assessed by different psychometrics scales to evaluate cognitive, social, economic and behavioral outcome. The results of all groups will be analysed by using Stata version 15 to evaluate the effect of ADHD and epilepsy in children and adolescent and identify the possible risk factors to improve outcome
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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group1
ADHD with normal EEG
electroencephalography
diagnosis epileptic discharge
psychometric scales to diagnosis psychiatric disorders
to diagnosis intellectual disability, attention deficit hyperactivity disorder ,epilepsy,autism and other mental illness.
psychometric scales for assesment socioeconomic and behaviour problems
to assessment other behavioural comorbidity as aggression ,mood changes,etc and help in identify function impairment, social and economic burden
group 2
ADHD with abnormal EEG
electroencephalography
diagnosis epileptic discharge
psychometric scales to diagnosis psychiatric disorders
to diagnosis intellectual disability, attention deficit hyperactivity disorder ,epilepsy,autism and other mental illness.
psychometric scales for assesment socioeconomic and behaviour problems
to assessment other behavioural comorbidity as aggression ,mood changes,etc and help in identify function impairment, social and economic burden
group 3
Epilepsy
electroencephalography
diagnosis epileptic discharge
psychometric scales to diagnosis psychiatric disorders
to diagnosis intellectual disability, attention deficit hyperactivity disorder ,epilepsy,autism and other mental illness.
psychometric scales for assesment socioeconomic and behaviour problems
to assessment other behavioural comorbidity as aggression ,mood changes,etc and help in identify function impairment, social and economic burden
group 4
Healthy control group
electroencephalography
diagnosis epileptic discharge
psychometric scales to diagnosis psychiatric disorders
to diagnosis intellectual disability, attention deficit hyperactivity disorder ,epilepsy,autism and other mental illness.
psychometric scales for assesment socioeconomic and behaviour problems
to assessment other behavioural comorbidity as aggression ,mood changes,etc and help in identify function impairment, social and economic burden
group 5
ADHD and epilepsy
electroencephalography
diagnosis epileptic discharge
psychometric scales to diagnosis psychiatric disorders
to diagnosis intellectual disability, attention deficit hyperactivity disorder ,epilepsy,autism and other mental illness.
psychometric scales for assesment socioeconomic and behaviour problems
to assessment other behavioural comorbidity as aggression ,mood changes,etc and help in identify function impairment, social and economic burden
Interventions
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electroencephalography
diagnosis epileptic discharge
psychometric scales to diagnosis psychiatric disorders
to diagnosis intellectual disability, attention deficit hyperactivity disorder ,epilepsy,autism and other mental illness.
psychometric scales for assesment socioeconomic and behaviour problems
to assessment other behavioural comorbidity as aggression ,mood changes,etc and help in identify function impairment, social and economic burden
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age range from 6- 11 years.
* Diagnosis of ADHD and/or epilepsy was verified and confirmed either on a clinical basis or by using reliable psychometric tests.
* In epilepsy groups: only Idiopathic type was included.
* Willing of the parents or the caregivers to participate in the study.
Exclusion Criteria
* Children with intelligence quotient below 70.
* Children with history or current substance use.
* Children with medical or other neurological conditions.
6 Years
11 Years
ALL
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Gellan Karamalllah Ramadan Ahmed
Assistent lecture
Principal Investigators
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Alaa El-Din Darweesh, PhD
Role: STUDY_DIRECTOR
Assiut University
HossamEddin Ahmad, PhD
Role: STUDY_CHAIR
Assiut University
Patrick Bolton, PhD
Role: STUDY_CHAIR
King's College London
Locations
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Assiut University Hospital
Asyut, , Egypt
Countries
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References
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Dunn DW, Austin JK, Huster GA. Behaviour problems in children with new-onset epilepsy. Seizure. 1997 Aug;6(4):283-7.
Kanner AM. The use of psychotropic drugs in epilepsy: what every neurologist should know. Semin Neurol. 2008 Jul;28(3):379-88. doi: 10.1055/s-2008-1079342. Epub 2008 Jul 24.
Chou IC, Chang YT, Chin ZN, Muo CH, Sung FC, Kuo HT, Tsai CH, Kao CH. Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. PLoS One. 2013;8(3):e57926. doi: 10.1371/journal.pone.0057926. Epub 2013 Mar 6.
Sherman EM, Slick DJ, Connolly MB, Eyrl KL. ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia. 2007 Jun;48(6):1083-91. doi: 10.1111/j.1528-1167.2007.01028.x. Epub 2007 Mar 22.
Kaufmann R, Goldberg-Stern H, Shuper A. Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. J Child Neurol. 2009 Jun;24(6):727-33. doi: 10.1177/0883073808330165.
Kirov R, Kinkelbur J, Banaschewski T, Rothenberger A. Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidity. J Child Psychol Psychiatry. 2007 Jun;48(6):561-70. doi: 10.1111/j.1469-7610.2007.01729.x.
Dickstein, L.J., Roba, M.B. and Oldham, J.M.(1997): Review of psychiatry. AmericanPsychiatric Press. Washington, DC. London,England.
Ahmed GK, Darwish AM, Khalifa H, Khashbah MA. Evaluation of psychiatric comorbidity in attention-deficit hyperactivity disorder with epilepsy: A case-control study. Epilepsy Res. 2021 Jan;169:106505. doi: 10.1016/j.eplepsyres.2020.106505. Epub 2020 Nov 21.
Other Identifiers
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Impact of ADHD and epilepsy
Identifier Type: -
Identifier Source: org_study_id
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