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Prevalence of Attention Deficit Hyperactivity Disorder and Its Comorbidities

NCT ID: NCT06146595

Last Updated: 2023-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-01

Study Completion Date

2025-11-01

Brief Summary

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Estimate the prevalence of attention deficit hyperactivity disorder and comorbid psychiatric disorder among primary school students in New Valley governorate.

Detailed Description

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ADHD (attention deficit hyperactivity disorder) is a common neurodevelopmental disorder characterized by hyperactivity, impulsivity, and inattention. Its prevalence ranges between 5.9 and 7.1% worldwide. Etiology of ADHD included combinations of genetic, neurological, and environmental factors. ADHD is more often a complex disorder with a high rate of associated comorbid conditions. Comorbid conditions are prevalent among people with ADHD and increase its burden and complexity of management. Children with ADHD are at a higher risk than children without ADHD for developing other psychiatric disorders. Most children with ADHD also have at least one comorbid condition, the presence of which contributes to poorer long-term outcomes. The pattern of comorbidities is influenced by age and sex; externalizing disorders are more common in younger ages and male participants, in contrast, internalizing disorders are more prevalent among older ages and female participants. Comorbidity involving ADHD and learning disorders is frequent, ranging from 25 to 40%. Other disorders likely to co-occur with ADHD are: bipolar disorders (11-75%), tic disorders (20%), obsessive compulsive disorders (6-15%). Children with ADHD may show several motor problems: longer and more variable reaction times, increased variability in speed and less accurate response reengagement, and impaired orienting responses, and increased number of responses with very long reaction times. Neurological soft sign have been associated with inattention and behavior difficulties for decades. Some researchers argue that these signs should be included in the diagnosis of ADHD.

Conditions

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ADHD

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

Age: 6-17 years. Sex: both sexes will be included in the study.

Exclusion Criteria

Age: less than 6 years or more than 17 years. Patients with major neurological deficits, cerebral palsy. Patient who refusing to participate in the study or their caregiver refusing to give informed consent. Mentally retarded children.
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Mahmood Mohammed Yosry Abdelsatar Mohammed

assistant lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Mahmoud Mohamed, assistant lecturer

Role: CONTACT

[email protected]
00201099636567

References

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Belanger SA, Andrews D, Gray C, Korczak D. ADHD in children and youth: Part 1-Etiology, diagnosis, and comorbidity. Paediatr Child Health. 2018 Nov;23(7):447-453. doi: 10.1093/pch/pxy109. Epub 2018 Oct 24.

Reference Type RESULT
PMID: 30681669 (View on PubMed)

Willcutt EG. The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Neurotherapeutics. 2012 Jul;9(3):490-9. doi: 10.1007/s13311-012-0135-8.

Reference Type RESULT
PMID: 22976615 (View on PubMed)

Becker SP, Langberg JM, Evans SW. Sleep problems predict comorbid externalizing behaviors and depression in young adolescents with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2015 Aug;24(8):897-907. doi: 10.1007/s00787-014-0636-6. Epub 2014 Oct 31.

Reference Type RESULT
PMID: 25359419 (View on PubMed)

Mohammadi MR, Zarafshan H, Khaleghi A, Ahmadi N, Hooshyari Z, Mostafavi SA, Ahmadi A, Alavi SS, Shakiba A, Salmanian M. Prevalence of ADHD and Its Comorbidities in a Population-Based Sample. J Atten Disord. 2021 Jun;25(8):1058-1067. doi: 10.1177/1087054719886372. Epub 2019 Dec 13.

Reference Type RESULT
PMID: 31833803 (View on PubMed)

Tung I, Li JJ, Meza JI, Jezior KL, Kianmahd JS, Hentschel PG, O'Neil PM, Lee SS. Patterns of Comorbidity Among Girls With ADHD: A Meta-analysis. Pediatrics. 2016 Oct;138(4):e20160430. doi: 10.1542/peds.2016-0430. Epub 2016 Sep 21.

Reference Type RESULT
PMID: 27694280 (View on PubMed)

Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Killian JM, Weaver AL, Katusic SK. Childhood ADHD is strongly associated with a broad range of psychiatric disorders during adolescence: a population-based birth cohort study. J Child Psychol Psychiatry. 2012 Oct;53(10):1036-43. doi: 10.1111/j.1469-7610.2012.02567.x. Epub 2012 May 31.

Reference Type RESULT
PMID: 22647074 (View on PubMed)

Gillberg C, Gillberg IC, Rasmussen P, Kadesjo B, Soderstrom H, Rastam M, Johnson M, Rothenberger A, Niklasson L. Co-existing disorders in ADHD -- implications for diagnosis and intervention. Eur Child Adolesc Psychiatry. 2004;13 Suppl 1:I80-92. doi: 10.1007/s00787-004-1008-4.

Reference Type RESULT
PMID: 15322959 (View on PubMed)

Cardo E, Casanovas S, de la Banda G, Servera M. [Soft neurological signs: are they of any value in the assessment and diagnosis of attention deficit hyperactivity disorder?]. Rev Neurol. 2008;46 Suppl 1:S51-4. Spanish.

Reference Type RESULT
PMID: 18302123 (View on PubMed)

Johansen EB, Aase H, Meyer A, Sagvolden T. Attention-deficit/hyperactivity disorder (ADHD) behaviour explained by dysfunctioning reinforcement and extinction processes. Behav Brain Res. 2002 Mar 10;130(1-2):37-45. doi: 10.1016/s0166-4328(01)00434-x.

Reference Type RESULT
PMID: 11864716 (View on PubMed)

Spencer TJ, Biederman J, Mick E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. J Pediatr Psychol. 2007 Jul;32(6):631-42. doi: 10.1093/jpepsy/jsm005. Epub 2007 Jun 7.

Reference Type RESULT
PMID: 17556405 (View on PubMed)

Jensen CM, Steinhausen HC. Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study. Atten Defic Hyperact Disord. 2015 Mar;7(1):27-38. doi: 10.1007/s12402-014-0142-1. Epub 2014 Jun 19.

Reference Type RESULT
PMID: 24942707 (View on PubMed)

Other Identifiers

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ADHD and its comorbidity

Identifier Type: -

Identifier Source: org_study_id