Identification of Biomarkers of Attention Deficit Disorder With or Without Hyperactivity (ADHD) by a Metabolomic Approach in Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

89 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-29

Study Completion Date

2019-11-12

Brief Summary

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Attention-deficit with or without hyperactivity disorder (ADHD) is a real health public concern. No easy-use diagnosis tool are available. Metabolomic approaches has brought very usefull data in others neurological diseases like amyotrophic lateral sclerosis or autism spectrum disorder, as we had shown in previous studies. Targeting on neurotransmitter pathways involving in ADHD, metabolomic screening could help to enhance our diagnosis power to better help numerus of children. We propose to study the phenylalanine and the tyrosine pathways with a multimodal metabolomic approach, in easy-available biological fluid (blood and urine), in child or adolescent suspected of ADHD. Our objectives are: 1- to determine a specific metabolomic signature of ADHD 2- to compare the diagnostic value of this metabolomic signature with the reference methodology for ADHD diagnosis, as now practiced in our reference center for learning troubles.

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Detailed Description

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Conditions

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Adhd

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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ADHD

Patient with ADHD diagnosis criterion. The aim is the identification of Biomarkers of ADHD by a Metabolomic Approach

Metabolomic approach

Intervention Type OTHER

Biological samples (blood and urine) for a multimodal metabolomic approach

non ADHD

Patient with symptom of hyperactivity and/or attention deficiency but without ADHD diagnosis criterion.

The aim is the identification of Biomarkers of ADHD by a Metabolomic Approach.

Metabolomic approach

Intervention Type OTHER

Biological samples (blood and urine) for a multimodal metabolomic approach

Interventions

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Metabolomic approach

Biological samples (blood and urine) for a multimodal metabolomic approach

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Child or adolescent with symptoms of attention disorders and / or hyperactivity
* aged from 6 to 15 years old

Exclusion Criteria

* Failure or refusal of all or part of the multidisciplinary evaluation (medical and / or neuropsychological assessments and / or biological assessments)
* Identification of an intercurrent condition likely to have an impact on metabolomic analyzes (acute infection, fever, etc.)
* Parents or legal guardians opposed to data processing

Minimum Eligible Age

6 Years

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No