MRI Maker of Perioperative Neurocognitive Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-12

Study Completion Date

2020-07-30

Brief Summary

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Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.

Detailed Description

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Conditions

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Necrosis of Femoral Head Knee Osteoarthritis Fracture of Lower Limb

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 60 years
* Spoke proficient Chinese
* Selected to lower limb osteopathic surgery
* Informed consent signed by the patient
* Underwent general anesthesia

Exclusion Criteria

* Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis
* Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
* Several audition or vision disorder
* With standard contraindications to MRI examinations
* Unwillingness to comply with the protocol or procedures.

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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qi lu, Dr.

Role: STUDY_DIRECTOR

Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

Locations

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Renji Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Diansan Su, Dr.

Role: CONTACT

Phone: +862168383702

Email: [email protected]

Facility Contacts

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Diansan Su

Role: primary

Other Identifiers

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2017-075

Identifier Type: -

Identifier Source: org_study_id