BPF Genetics of ILD Study

NCT ID: NCT03747627

Last Updated: 2025-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

475 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-19

Study Completion Date

2028-01-01

Brief Summary

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The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group.

We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.

Detailed Description

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The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings.

Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements.

Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.

Conditions

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Lung; Disease, Interstitial, With Fibrosis Alveolitis, Extrinsic Allergic Bird Fancier's Lung Idiopathic Interstitial Pneumonias Lung Diseases, Interstitial Idiopathic Pulmonary Fibrosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Genetic profiling

All participating subjects will undergo detailed genetic analysis, with the aim of detecting novel genetic drivers for the development of interstitial lung disease in the context of known sensitising agent (pigeon antigen)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* regular exposure to racing pigeons

Exclusion Criteria

* Unwilling to participate
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Leicester

OTHER

Sponsor Role collaborator

University of Glasgow

OTHER

Sponsor Role collaborator

Newcastle University

OTHER

Sponsor Role collaborator

British Lung Foundation

OTHER

Sponsor Role collaborator

British Pigeon Fanciers Medical Research

UNKNOWN

Sponsor Role collaborator

University of Dundee

OTHER

Sponsor Role lead

Responsible Party

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Mark Spears

Dr Mark Spears, Consultant in Respiratory Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mark Spears, PhD, FRCP

Role: PRINCIPAL_INVESTIGATOR

NHS Tayside & University of Dundee

Louise Wain, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Leicester

Locations

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Scottish Homing Union

Lanark, Lanark, United Kingdom

Site Status

Royal Pigeon Racing Association Meeting

Blackpool, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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MS001

Identifier Type: -

Identifier Source: org_study_id

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