Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH

NCT ID: NCT03735862

Last Updated: 2019-10-01

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

85 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-01

Study Completion Date

2018-10-01

Brief Summary

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Investigator will identify a consecutive cohort of patients who have undergone a hiatal hernia repair and are at least 6 months post index procedure.

Detailed Description

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Planned Sample Size: At minimum of 70 consecutive subjects at least 6-months post-index procedure

Study Population: A consecutive cohort of patients who have undergone a hiatal hernia repair with MIROMESH.

Primary Objective: Characterize the procedural and early post-operative safety profile of MIROMESH when used as reinforcement in hiatal hernia repair.

Secondary Objectives

A retrospective chart review will identify the appropriate cohort with a prospective follow-up survey to acquire safety and outcome information.

A retrospective chart review of appropriate subjects.

Data to be acquired will be:

Preoperative - Chart Review

* Gender
* Date of birth
* Weight
* Body Mass Index
* Specific diagnosis
* DeMeester Score
* 24 hour pH test (% acid exposure in 24 hours)
* Gastroesophageal Reflux Disease Health Related Quality of Life (GERD-HRQL) Score Peri-operative Preoperative - Chart Review
* Date of surgery
* Number of stitches used to close wound
* Paraesophageal hernia type
* Mesh shape
* Mesh size used
* Attachment technique
* Length of stay
* Complications

Post-Operative (With-in 1 month of surgery) Preoperative - Chart Review

* Complications (Mesh related)
* Complications (procedure related)
* Prolonged dysphagia (Y/N)
* Stenosis (Y/N)
* Dilations (Y/N)
* Esophagogastroduodenoscopy or Upper gastrointestinal series documented hernia recurrence
* GERD-HRQL Score

Prospective institutional review board approved Follow-Up Telephone Interview

* Have you had a revision surgery?
* GERD-HRQL Score
* How satisfied are you with the procedure?
* Have you used proton pump inhibitors in the last 3 months
* How likely are you to recommend this procedure to a loved one?

Conditions

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Hiatal Hernia With Gastroesophageal Reflux Disease Gastroesophageal Reflux GERD

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Observations Group

Patients who have undergone a hiatal hernia repair with MIROMESH.

Hepatic derived surgical matrix

Intervention Type BIOLOGICAL

Hiatal hernia repair with MIROMESH

Interventions

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Hepatic derived surgical matrix

Hiatal hernia repair with MIROMESH

Intervention Type BIOLOGICAL

Other Intervention Names

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MIROMESH Biologic Matrix

Eligibility Criteria

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Inclusion Criteria

* Had a hiatal hernia repair with MIROMESH greater than 6 months prior to study

Exclusion Criteria

* N/A
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Miromatrix Medical Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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George K Gillian, M.D.

Role: PRINCIPAL_INVESTIGATOR

Virginia Heartburn and Hernia Institute

Locations

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Virginia Heartburn and Hernia Institute

Lorton, Virginia, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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20174001

Identifier Type: -

Identifier Source: org_study_id

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